Clinical analysis of morphine hydrochloride sustainedrelease tablets combined with celecoxib in the treatment of advanced lung cancer with moderate to severe cancerinduced pain

doi:10.3760/cma.j.issn.1673422X.2017.03.002

Abstract

Abstract: ObjectiveTo explore the efficacy, safety and life quality of patients of morphine hydrochloride sustainedrelease tablets combined with celecoxib in the treatment of advanced lung cancer with moderate to severe cancerinduced pain. MethodsA total of 247 patients of advanced lung cancer with moderate to severe cancerinduced pain were randomly divided into combination therapy group (n=127) and morphine monotherapy group (n=120) using simple random sampling digital table method. The differences of dose, efficacy, adverse drug reactions and life quality between the two groups were analyzed. ResultsIn achieving similar analgesic effect, the average maintenance dose of morphine in combination therapy group was (52.51±19.92)mg/d, lower than that in monotherapy group ［(58.75±20.64)mg/d, t=-2.414, P=0.017］. The incidence of constipation in combination therapy group was 34.6%, lower than that in monotherapy treatment group (47.5%, χ2=4.218, P=0.040). The life quality of the two groups were improved, and the life quality improvement rate in combination therapy group was 59.8%, higher than that in monotherapy treatment group (43.3%, χ2=6.736, P=0.009). ConclusionMorphine hydrochloride sustainedrelease tablets combined with celecoxib is effective in the treatment of moderate to severe cancer pain, which can reduce the dosage of morphine and reduce adverse reaction, so as to improve the life quality of the patients with advanced lung cancer.

Key words: Lung neoplasms, Quality of life, Morphine, Celecoxib, Cancer pain

Li Xueqin, Chen Xi, Gong Quan, Shi Wei, Zhang Lijuan, Dong Hui, Wang Cunde. Clinical analysis of morphine hydrochloride sustainedrelease tablets combined with celecoxib in the treatment of advanced lung cancer with moderate to severe cancerinduced pain[J]. Journal of International Oncology, 2017, 44(3): 165-168.

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