Abstract: ObjectiveTo investigate the incidence and epidemiological characteristics of esophageal cancer in Kashgar region, and to provide theoretical basis for the comprehensive prevention and treatment of esophageal cancer. MethodsA total of 1 815 cases of esophageal cancer were collected from January 2015 to December 2015. The morbid feature was analyzed and fittingconditional Logistic model multivariate analysis was used to infer the influence factors. ResultsIn 1 815 cases of esophageal cancer, the sex ratio was 2.4/1.0, and there were more men than women (χ2=5.90, P=0.015). Age of onset was mainly focused on 5170 years old. The incidence rate of Shule County was the highest. Logistic model multivariate analysis showed that esophageal cancer was closely related to the three factors: fast food intaking speed (χ2=17.756, P＜0.001), hot eating habit (χ2=8.234, P=0.003) and history of stomach diseases (χ2=14.421, P＜0.001). ConclusionThe morbidity of esophageal cancer maintains a high level in Kashgar region, which may be related to the local residents life habits, history of stomach diseases and other factors. Comprehensive strategy of prophylaxis and treatment must be taken.

Key words: Esophageal neoplasms, Epidemiology, Kashgar region