Research progress on resistance mechanisms of anti-PD-1/PD-L1 therapy in advanced non-small cell lung cancer

doi:10.3760/cma.j.cn371439-20250319-00008

Abstract

Abstract:

Although immune checkpoint inhibitor therapy based on anti-programmed death-1 （PD-1） and programmed death-ligand 1 （PD-L1） can significantly improve the survival prognosis of patients with advanced non-small cell lung cancer， primary and secondary drug resistance result in limited benefits for some individuals. The resistance mechanism of anti-PD-1/PD-L1 therapy is particularly complex and is influenced by multiple factors. A systematic review of the latest research results on the resistance mechanism to PD-1/PD-L1 immune checkpoint inhibitors can provide scientific basis for optimizing the treatment strategy of non-small cell lung cancer patients.

Key words: Carcinoma， non-small-cell lung, Immune checkpoint inhibitors, Tumor microenvironment, Drug resistance，neoplasm

Li Ting, Zhou Qi, Zhang Qian, Chen Jie. Research progress on resistance mechanisms of anti-PD-1/PD-L1 therapy in advanced non-small cell lung cancer[J]. Journal of International Oncology, 2026, 53(1): 57-61.

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