国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (4): 293-295.doi: 10.3760/cma.j.issn.1673422X.2016.04.014

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藤黄酸的抗肿瘤机制

张文典, 徐祖敏, 余忠华   

  1. 524001湛江，广东医学院附属医院肿瘤中心
  • 出版日期:2016-04-08 发布日期:2016-03-02
  • 通讯作者: 余忠华，Email: zhonghua_yu@126.com E-mail:zhonghua_yu@126.com

Antitumor mechanism of gambogic acid

Zhang Wendian, Xu Zumin, Yu Zhonghua   

  1. Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
  • Online:2016-04-08 Published:2016-03-02
  • Contact: Yu Zhonghua E-mail:zhonghua_yu@126.com

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1591

被引次数

1

摘要： 目前发现藤黄酸可通过不同机制在多种肿瘤细胞中发挥抗肿瘤作用，包括诱导细胞凋亡，抑制端粒末端转移酶和拓扑异构酶活性，抑制热休克蛋白和通道蛋白表达，抑制肿瘤血管生成和转移，逆转肿瘤多药耐药，提示藤黄酸有望成为新型抗肿瘤药物，且仍需进一步探索其在抗肿瘤领域的价值。

关键词: 藤黄属, 抗肿瘤药, 肿瘤

Abstract: It is found that gambogic acid can play antitumor effects through different mechanisms in a variety of tumor cells, including induce apoptosis, inhibit telomerase and topoisomerase activity, inhibit the expression of heat shock protein and channel protein, inhibit tumor angiogenesis and metastasis and reverse multidrug resistance. Gambogic acid is expected to become a new antitumor drug, still need to be further explored its value in the field of antitumor.

Key words: Garcinia, Antineoplastic agents, Neoplasms