国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (11): 866-868.doi: 10.3760/cma.j.issn.1673422X.2015.11.019

• 综述 • 上一篇    下一篇

肝癌干细胞的生物学研究

陈飞宇,张安娜,任钧国   

  1. 100091北京中医药大学研究生学院（陈飞宇）；中国中医科学院西苑医院基础医学研究所（陈飞宇、张安娜、任钧国）
  • 出版日期:2015-11-08 发布日期:2015-09-30
  • 通讯作者: 任钧国，Email：reek2003@163.com E-mail:reek2003@163.com
  • 基金资助:

    中国中医科学院基本科研业务费自主选题项目（ZZ0708099）

Biological research of liver cancer stem cells

Chen Feiyu, Zhang Anna, Ren Junguo.   

  1. Graduate School of Beijing University of Chinese Medicine ＆  Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Ren Junguo E-mail:reek2003@163.com

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摘要： 肝癌干细胞对肝癌的发生、转移有重要作用。目前，关于肝癌干细胞的来源有成熟肝细胞的去分化和肝干细胞的成熟分化受阻两种说法，分选方法有侧群细胞分选法和表面标记分选法，靶向作用于肝癌干细胞群，有望成为一种有效的肝癌治疗手段。

关键词: 肝肿瘤, 肿瘤干细胞, 生物学

Abstract: Liver cancer stem cell plays an important role in hepatocarcinoma occurrence and metastasis.Presently,the two theories about the source of liver cancer stem cells are mature hepatocytes′ dedifferentiation and hepatic stem cells′ blocked differentiation.Side population cell sorting and different surface antigen labeling are general sorting methods of hepatocarcinoma stem cells.Targeting the liver cancer stem cells population provides an effective way to the treatments of liver neoplasms.

Key words: Liver neoplasms, Neoplastic stem cells, Biology