国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (11): 863-865.doi: 10.3760/cma.j.issn.1673422X.2015.11.018

• 综述 • 上一篇    下一篇

miR-375在消化系统肿瘤中的表达及作用

陈征,刘晓峰,董倩倩,麻树霖   

  1. 250000 济南军区总医院消化内科
  • 出版日期:2015-11-08 发布日期:2015-09-30
  • 通讯作者: 刘晓峰，Email:liuxf0531@126.com E-mail:liuxf0531@126.com

Expression and role of miRNA375 in digestive system tumors

Chen Zheng, Liu Xiaofeng, Dong Qianqian, Ma Shulin.   

  1. Department of Gastroenterology， General Hospital of Ji′nan Military Commend， Ji′nan 250000， China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Liu Xiaofeng E-mail:liuxf0531@126.com

PDF

1035

摘要： 微小RNA通过调节基因转录后水平的表达在生物学过程发挥重要作用。越来越多的研究发现miR375在消化系肿瘤中普遍低表达，与肿瘤的发生有关。过表达的miR375可通过抑制靶基因的表达起到抑制肿瘤生长、转移的作用。

关键词: 微RNAs, 消化系统肿瘤, 肿瘤转移

Abstract: microRNA (miRNA) plays an important role in biological processes via regulating gene expression in the level of posttranscription. Increasing number of studies reveal that miR375 is downregulated in digestive system tumors, and is related to tumorigenesis. Overexpression of miR375 can inhibit growth and metastasis of tumors through repressing the expression of target genes.

Key words: MicroRNAs, Digestive system neoplasms, Neoplasm metastasis