国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 460-463.doi: 10.3760/cma.j.issn.1673-422X.2014.06.021

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JAK/STAT信号通路与急性白血病

庄晏, 刘立根   

  1. 200240 复旦大学附属上海市第五人民医院血液内科 复旦大学血液病研究中心
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 通讯作者: 刘立根， E-mail: liuligen@medmail.com.cn E-mail:liuligen@medmail.com.cn
  • 基金资助:

    国家自然科学基金资助项目（30672415）

JAK/STAT pathway and its role in acute leukemia

ZHUANG  Yan, LIU  Li-Gen   

  1. Department of hematology , Fifth People’s Hospital of Shanghai, Fudan University, Hematology Research Center of Fudan University, Shanghai 200240, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Liu Ligen E-mail:liuligen@medmail.com.cn

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被引次数

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摘要： JAK/STAT信号通路是由多种细胞因子与受体结合激活的中心通路，参与肿瘤的增殖、分化和凋亡过程。研究表明，血液细胞中JAK/STAT突变及调控异常对急性白血病发生发展起重要作用。探讨此通路异常的同时也为治疗急性白血病提供新靶点。

关键词: font-size: 12pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-bidi-font-family: 宋体">白血病, 治疗, font-size: 12pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体" lang="EN-US">JAK/STATfont-size: 12pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-bidi-font-family: 宋体, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">信号通路

Abstract: JAK/STAT pathway is a central signaling activated by cytokines binding with their relative receptors which can regulate cell proliferation, differentiation and apoptosis. Recent studies have suggested that abnormal signaling pathway with gene mutation and dysregulation plays an important part in the pathogenesis and progression of acute leukemia. Increasing investigation of this pathway may provide novel target therapies.

Key words: font-size: 12pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体" lang="EN-US">Acute leukemia, Therapy, JAK/STAT pathway