内质网应激在肿瘤发展中的作用

doi:10.3760/cma.j.issn.1673-422X.2014.02.002

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (2): 84-87.doi: 10.3760/cma.j.issn.1673-422X.2014.02.002

内质网应激在肿瘤发展中的作用

马瑞金, 杨宇

150086哈尔滨医科大学附属第二医院肿瘤内科

收稿日期:2013-09-24 修回日期:2014-01-02 出版日期:2014-02-08 发布日期:2014-01-26
通讯作者: 杨宇，E-mail: yangy@medmail.com.cn E-mail:yangy@medmail.com.cn
基金资助:
黑龙江省自然科学基金（D200862）

Role of endoplasmic reticulum stress in tumor progression

Ma Ruijin, Yang Yu

Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Received:2013-09-24 Revised:2014-01-02 Online:2014-02-08 Published:2014-01-26
Contact: Yang Yu E-mail:yangy@medmail.com.cn

摘要/Abstract

摘要： 内质网应激(ERS)作为一种细胞应激过程，在多种细胞、多种情况下可被激活。近年来发现，ERS存在于多种肿瘤细胞中。体内外研究证实ERS参与介导肿瘤细胞的凋亡、自噬性死亡和免疫原性细胞死亡，以及促进肿瘤细胞存活、调控细胞周期等多个过程，从而在肿瘤细胞中发挥多种作用。因此研究ERS将有助于进一步了解肿瘤的发展及转归。

关键词: 肿瘤, 细胞凋亡, 自噬, 内质网应激

Abstract: Endoplasmic reticulum stress (ERS) as a cell stress, can be activated in a variety of cells and situations. In recent years, researches show that ERS exists in many kinds of tumor cells so as to play a number of roles in inducing cell apoptosis, autophagymediated apoptosis, immunogenic cell death, promoting tumor cell survival, regulating the cell cycle. So study on ERS is helpful to understand the development and the outcome of tumor.

Key words: Neoplasms, Apoptosis, Autophagy, Endoplasmic reticulum stress

马瑞金, 杨宇. 内质网应激在肿瘤发展中的作用[J]. 国际肿瘤学杂志, 2014, 41(2): 84-87.

Ma Ruijin, Yang Yu. Role of endoplasmic reticulum stress in tumor progression[J]. Journal of International Oncology, 2014, 41(2): 84-87.

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内质网应激在肿瘤发展中的作用

Role of endoplasmic reticulum stress in tumor progression

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