CRD-BP和β-TrCP在结直肠癌中的研究

doi:10.3760/cma.j.issn.1673-422X.2013.12.016

摘要/Abstract

摘要： 不稳定编码区(CRD)是cmyc基因的影响因素之一。不稳定编码区结合蛋白(CRDBP)与CRD结合可使CRD免受核酸内切酶攻击，阻止cmyc mRNA快速降解，增加cmyc蛋白含量。β转导重复相容蛋白(βTrCP)可对多个信号通路及细胞周期进行调控，影响细胞生长、分化、凋亡及肿瘤形成。CRDBP高表达进而上调βTrCP，与结直肠癌的发生发展、转移侵袭等密切相关。

关键词: 结直肠肿瘤, 信号传导, 不稳定编码区结合蛋白, &beta, -转导重复相容蛋白

Abstract: Coding region instability determinant (CRD) is one of the influence factors of oncogene cmyc. Coding region instability determinantbinding protein (CRDBP) can connect with CRD in order to protect CRD from nuclease attack, prevent rapid degradation of cmyc mRNA, and increase cmyc protein content. Betatransducin repeatscontaining protein (βTrCP) can affect cell growth, differentiation, apoptosis and oncogenesis by regulating multiple signaling pathways and cell cycle. The overexpression of CRDBP can upregulate the expression of βTrCP and both of them play important roles in the tumorigenesis, progression, metastasis and invasion of colorectal cancer.

Key words: Colorectal neoplasms, Signal transduction, Coding region instability determinant-binding protein, Beta-transducin repeats-containing protein

程莉, 程丽, 贾丹丹, 戚文娟, 周长江. CRD-BP和β-TrCP在结直肠癌中的研究[J]. 国际肿瘤学杂志, 2013, 40(12): 930-932.

CHENG Li, CHENG Li, JIA Dan-Dan, QI Wen-Juan, ZHOU Chang-Jiang. CRD-BP and β-TrCP in colorectal cancer[J]. Journal of International Oncology, 2013, 40(12): 930-932.

参考文献

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