国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 726-729.

• 综述 • 上一篇    下一篇

MiR-494在肿瘤中的作用

黎明春, 吴爱兵, 杨志雄   

  1. 524001 湛江， 广东医学院附属医院肿瘤中心一区

  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 杨志雄，E-mail：yangzhixiong068@126.com E-mail:yangzhixiong068@126.com
  • 基金资助:

    广东省科技计划项目（2011B031800324）

Roles of miR-494 in tumors

LI  Ming-Chun, WU  Ai-Bing, YANG  Zhi-Xiong   

  1. First Departerment of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: YANG Zhi-xiong, E?-mail: yangzhixiong068@126.com E-mail:yangzhixiong068@126.com

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被引次数

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摘要： miR-494参与正常细胞的细胞周期调控、分化和凋亡等过程。近年来研究表明，miR-494的异常表达与肿瘤的发生密切相关，其参与肿瘤细胞的侵袭和转移等过程。miR-494是一种肿瘤抑制基因，也可作为癌基因。其通过多种靶基因、信号通路对肿瘤发生发展进行调控。

关键词: 微RNAs, 肿瘤, 靶基因

Abstract: MiR-494 involves in cell cycle regulation, differentiation and apoptosis processes of normal cells. Recent study shows that abnormal expression of miR-494 is associated with oncogenesis closely, and it participates in the invasion and metastasis of tumor cells and so on. MiR-494 is not only a tumor suppressor gene, but also can be considered as a cancer-promoting gene. MiR-494 can regulate the oncogenesis and development of the tumor through a variety of target genes and signaling pathways.

Key words: MicroRNAs, Neoplasms, Target gene