国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 723-726.

• 综述 •    下一篇

Pim-1在肿瘤及相关信号通路中的作用

梁至洁, 贾苗苗, 张斌, 等   

  1. 作者单位：300060 天津医科大学附属肿瘤医院乳腺一科乳腺癌防治教育部重点实验室 天津市肿瘤防治重点实验室

  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 曹旭晨，E-mail: cxc@medmail.com.cn E-mail:cxc@medmail.com.cn
  • 基金资助:

    天津市自然科学基金（11JCZDJ28000）

Roles of Pim-1 in tumors and related signaling pathways

LIANG  Zhi-Jie, JIA  Miao-Miao, ZHANG  Bin, et al   

  1. First Department of Breast Surgery, Affiliated Cancer Hospital of Tianjin Medical University; Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education; Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: Cao Xu-chen, E-mail: cxc@medmail.com.cn E-mail:cxc@medmail.com.cn

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摘要： 原癌基因蛋白质c-pim-1(Pim-1)在肿瘤组织中常表达增高且与肿瘤分期、预后密切相关。近来研究表明，Pim-1不仅参与调控细胞增殖和凋亡，在肿瘤转移过程中也发挥重要作用。多个信号传导通路可以调控Pim-1表达与活化，同时Pim-1也可影响通路中多个重要因子，其在肿瘤发生发展中作用十分广泛，已成为肿瘤治疗的潜在靶点。

关键词: 原癌基因蛋白质c-pim-1, 肿瘤, 蛋白质丝氨酸苏氨酸激酶, 信号传导

Abstract: The overexpression of proto-oncogene proteins c-pim-1 (Pim-1) in tumor tissue is related to the stage and prognosis. Recent studies indicate that Pim-1 plays a critical role in the proliferation and apoptosis of cells and the metastasis of tumor. Pim-1 acts as an essential factor in several signaling pathways and its expression and activation are regulated by many factors as well as affects others widely. As an influential factor in the occurrence and development of tumor, Pim-1 has been a potential target in oncotherapy.

Key words: Proto-oncogene proteins c-pim-1, Neoplasms, Protein-serine-threonine kinases, Signal transduction