国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 646-648.

• 综述 • 上一篇    下一篇

赖氨酰氧化酶前肽与肿瘤

杨杰, 朱红   

  1. 650031，昆明医科大学研究生院（杨杰）；昆明医科大学第二附属医院肝胆胰外科（朱红）
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 朱红，E-mail: zhuhongkm@sina.com E-mail:zhuhongkm@sina.com

Lysyal oxidase propeptide and tumor

YANG  Jie, ZHU  Hong   

  1. Graduate School, Kunming Medical University, Kunming 650031, China

  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: ZHU Hong, E-mail: zhuhongkm@sina.com E-mail:zhuhongkm@sina.com

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摘要： 赖氨酰氧化酶（LOX）是一种铜依赖的单胺类氧化酶，能稳定细胞外基质，与肿瘤细胞分化、恶性转化和侵袭性密切相关。赖氨酰氧化酶前肽（LOX-PP）是LOX分泌到细胞外，在溶胶蛋白酶的作用下被分解成的一个片段，研究发现LOX-PP具有自身特有的结构及生物学功能，并能够抑制肿瘤细胞的生长，在肿瘤细胞发生、发展过程中具有重要的作用。LOX-PP成为当前研究热点，有望成为肿瘤治疗的新靶点。

关键词: 蛋白赖氨酸6-氧化酶, 肿瘤, 基因, 肿瘤抑制

Abstract: Lysyal oxidase (LOX), a cooper dependent monoamine oxidase, can stabilize the extracellular matrix and is closely related to the tumor cell differentiation, vicious transformation and invasiveness. LOX is secreted into extracellular, and it is resolved into a small fragment by sol protease, which is lysyal oxidase propeptide (LOX-PP). According to research, LOX-PP has its own structure and physiological functions,which can inhibit the growth of tumor cells. LOX-PP also plays a significant role in the generation and progression of tumor cells. LOX-PP is the hot spot of research currently, and it’s likely to be a new therapeutic target.

Key words: Protein-lysine 6-oxidase, Neoplasms, Genes, tumor suppressor