国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 643-645.

• 综述 • 上一篇    下一篇

血清胸苷激酶1与肿瘤

徐文静, 刘德干   

  1. 225700江苏省兴化市人民医院肿瘤科
  • 出版日期:2013-09-08 发布日期:2013-09-16
  • 通讯作者: 徐文静，E-mail: 2007xuwenjing@163.com E-mail:2007xuwenjing@163.com

Serum thymidine kinase 1 and cancer

XU  Wen-Jing, LIU  De-Gan   

  1. Department of Oncology, Xinghua People's Hospital of Jiangsu Province, Xinghua 225700, China
  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: XU Wen-jing, E-mail: 2007xuwenjing@163.com E-mail:2007xuwenjing@163.com

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2005

被引次数

2

摘要： 胸苷激酶1(TK1)是一种嘧啶补救途径的激酶，能催化脱氧胸苷磷酸化为一腺胸苷酸，与细胞周期调控和细胞增殖密切相关。多项试验表明，TK1可用于健康体检、肿瘤筛查、常规检测、疗效监视和预后，是一种灵敏有效地评估人体肿瘤增长的标志物。

关键词: 肿瘤, 胸苷激酶, 免疫组织化学

Abstract: Thymidine kinase 1 (TK1), an enzyme of the pyrimidine remedial pathway, can catalyze phosphorylation of thymidine to thymidine monophosphate. It is closely related to cell cycle regulation and cell proliferation. A number of experiments show that TK1 can be used for physical examination, tumor screening, routine testing, effect monitoring and prognosis, which is considered to be a sensitive and useful marker for human tumor growth.

Key words: Neoplasms, Thymidine kinase, Immunohistochemistry