国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 608-611.

• 综述 • 上一篇    下一篇

肝细胞肝癌上皮间质转化的相关分子机制

叶英楠, 王越, 王扬等   

  1. 300060 天津医科大学附属肿瘤医院 天津市“肿瘤防治”重点实验室
  • 出版日期:2013-08-08 发布日期:2013-08-15
  • 通讯作者: 于津浦，E-mail: jinpu_yu@hotmail.com E-mail:jinpu_yu@hotmail.com
  • 基金资助:

    国家重点基础研究发展计划（2012CB933304）；国家自然科学基金（81272360）

Molecular mechanisms of epithelial-mesenchymal transition in hepatocellular carcinoma

YE  Ying-Nan, WANG  Yue, WANG  Yang, et al   

  1. Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
  • Online:2013-08-08 Published:2013-08-15
  • Contact: Corresponding author：YU Jin-pu，E-mail: jinpu_yu@hotmail.com E-mail:jinpu_yu@hotmail.com

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1894

被引次数

6

摘要： 侵袭和转移是造成肝细胞肝癌(HCC)预后不良的重要因素。近年来，HCC上皮间质转化（EMT）已经被认为是HCC侵袭、转移的关键细胞学基础。尽管引起和维持EMT的分子机制并没有被完全阐明，但是转化生长因子-β(TGF-β)、磷脂酰肌醇3激酶（phosphatidyl inositol 3-kinase,PI3K）/蛋白激酶B（AKT）、细胞核转录因子-κB (NF-κB)、Wnt/β-连接素（β-catenin） 等细胞信号通路在EMT过程中的所起到的重要作用已经被证实。上述通路通过调控EMT过程直接或间接影响HCC的预后，这也为HCC的新型靶向药物的研究提供了分子基础。

关键词: 癌, 肝细胞, 细胞转化, 肿瘤, 转化生长因子β

Abstract: The poor prognosis of hepatocellular carcinoma (HCC) is strongly associated with invasion and metastasis. Recently, the epithelial-mesenchymal transition (EMT) has been confirmed to be the cytological foundation of invasion and metastasis. Yet, the molecular mechanism of inducing and maintaining EMT has not been expounded completely. However,it has been demonstrated that transforming growth factor-β(TGF-β), phosphatidyl inositol 3-kinase/ protein kinase B( PI3K/AKT),nuclear factor-κB(NF-κB),Wnt/β-catenin signaling pathways play pivotal roles in the initiation and development of EMT. These signaling pathways can affect the prognosis of HCC by regulating EMT. From a drug development perspective, these signal pathways are potential and attractive targets for HCC treatment.

Key words: Carcinoma, hepatocellular, Cell transformation, neoplastic, Transforming growth factor beta