国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 587-590.

• 综述 • 上一篇    下一篇

白藜芦醇对肿瘤中微小RNA的调节作用

季佳文, 周怀君   

  1. 210008南京中医药大学中西医结合鼓楼临床医学院妇产科
  • 出版日期:2013-08-08 发布日期:2013-08-15
  • 通讯作者: 周怀君，E-mail:zhouhj2007@126.com E-mail:zhouhj2007@126.com

Regulation role of resveratrol in microRNAs expression in cancers

JI  Jia-Wen, ZHOU  Huai-Jun   

  1. Department of  Gynecology and Obstetrics, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 21008, China

  • Online:2013-08-08 Published:2013-08-15
  • Contact: Corresponding author: ZHOU Huai-jun，E-mail: zhouhj2007@126.com E-mail:zhouhj2007@126.com

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被引次数

3

摘要： 白藜芦醇作为一种多酚类植物抗毒素，具有抗肿瘤、抗炎和促进代谢等保护性作用。在结肠癌、乳腺癌等不同肿瘤中白藜芦醇可能是通过上调抑癌微小RNA及下调致癌微小RNA表达，并且影响其相关通路的靶基因而起到抗肿瘤的作用。这为进一步明确白藜芦醇的抗肿瘤作用机制以及将白藜芦醇应用至临床提供了新的理论依据。

关键词: 微RNAs, 肿瘤, 白藜芦醇

Abstract: As a kind of polyphenolic phytoalexin, resveratrol exerts protective roles in anti-tumor, anti-inflammatory and promoting metabolism. Resveratrol’s anti-tumor mechanisms may be involved in upregulating tumor suppressor microRNAs and downregulating oncogenic microRNAs, and affect its relative pathways and target genes in different cancers such as colon cancers and breast cancers. This will provide a new theoretical basis for the further clarification of resveratrol-associated tumor suppressing mechanisms and its application to the clinical.

Key words: MicroRNAs, Neoplasms, Resveratrol