国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 494-497.

• 综述 • 上一篇    下一篇

多药耐药基因及相关耐药蛋白在肿瘤中的研究进展

邵松军,张湘宁,黄培春   

  1. 524001  湛江, 广东医学院病理生理教研室
  • 出版日期:2013-07-08 发布日期:2013-07-08

SHAO  Song-Jun, ZHANG  Xiang-Ning, HUANG  Pei-Chun   

  1. Department of Pathophysiological, Guangdong Medical College, Zhanjiang 524001, China
  • Online:2013-07-08 Published:2013-07-08

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被引次数

1

摘要： 化疗是肿瘤治疗的重要方法之一，但多药耐药(MDR)一直是影响其疗效的主要因素。肿瘤细胞中MDRl基因的扩增及其相关耐药蛋白的过度表达，细胞周期和细胞凋亡通路的信号转导相关机制的改变等，是导致化疗失败的重要原因。

关键词: 抗药性, 肿瘤, 多药耐药相关蛋白质类, 细胞周期, 肿瘤干细胞

Abstract: Chemotherapy is one of the most important methods of cancer treatment. However, multidrug resistance (MDR) has been the main factors affecting their efficacies. Recent studies show that the amplification of MDRl gene in tumor cells, the over expression of the related drug resistance protein and the cell cycle and apoptosis pathway in signal transduction are the main causes for the failure of chemotherapy.

Key words:  Drug resistance, neoplasms, Multidrug resistance-associated proteins, Cell cycle, Neoplastic stem cells