国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 332-335.

• 综述 • 上一篇    下一篇

髓系抑制性细胞与肿瘤

邵丽娟, 王若雨, 吴婷婷, 赵勇   

  1. 116001大连大学附属中山医院肿瘤内科(邵丽娟、王若雨)；中国科学院动物研究所生物膜与膜生物国家重点实验室（吴婷婷、赵勇）
  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 通讯作者: 赵勇 E-mail:zhaoy@ioz.ac.cn
  • 基金资助:

    科技部国家重点基础研究发展计划(2010CB945301)

Myloied derived suppressor cells and cancer

SHAO  Li-Juan, WANG  Ruo-Yu, WU  Ting-Ting, ZHAO  Yong   

  1. Department of Oncology, Afflicated Zhongshan Hospital of Dalian University, Dalian 116001, China
  • Online:2013-05-08 Published:2013-05-15
  • Contact: ZHAO Yong E-mail:zhaoy@ioz.ac.cn

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摘要： 髓系抑制性细胞（MDSC）是一群髓系来源具有抑制功能的天然免疫细胞，在肿瘤进展中发挥负向免疫调控作用。MDSC具有强大的抑制功能及显著的异质性，通过多种机制调控固有免疫及适应性免疫系统，发挥促肿瘤作用，同时可通过非免疫机制促进肿瘤血管生成及肿瘤转移等。近年来对其分化、增殖、抑制功能等的研究日趋成熟，由此衍生的靶向针对MDSC的肿瘤免疫治疗研究将为肿瘤疫苗的增效及肿瘤的治疗等带来新的希望。

关键词: 肿瘤, 髓系细胞, 髓系抑制性细胞, 靶向治疗

Abstract: Myeloid derived suppressor cells（MDSCs）are a subpopulation of immunosuppressive innate immune cells derived from bone marrow stem cells, which negatively regulate immune response in tumor progression. MDSCs have a powerful  suppressive function and significant heterogeneity. They can modulate innate and adaptive immune responses through a variety of mechanisms to promote the development of tumor, and also facilitate angiogenesis and metastasis of tumor via non immunologic mechanisms. In recent years, as increasingly mature research for the differentiation, proliferation and suppressive function of MDSCs, the derived  researches of MDSC-targeted tumor immunotherapy will finally contribute to increasing the efficiency of vaccine and tumor therapy in the future.

Key words: Neoplasms, Myeloid cells, Myloied derived suppressor cells, Targeted therapy