国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 184-186.

• 综述 • 上一篇    下一篇

Bmi-1基因与放射抵抗的相关研究

熊蓓蓓,范华,李涛   

  1. 646000  泸州医学院附属医院肿瘤科（熊蓓蓓，范华）；四川省肿瘤医院放疗科（李涛）
  • 出版日期:2013-03-08 发布日期:2013-02-25
  • 通讯作者: 李涛，E-mail: E-mail:litaoxmf@126.com
  • 基金资助:

    四川省2012年第一批科技计划项目（2012SZ0081）

Bmi-1 gene and radiation resistance

XIONG  Bei-Bei, FAN  Hua, LI  Tao   

  1. Department of Oncology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China
  • Online:2013-03-08 Published:2013-02-25
  • Contact: LI Tao, E-mail: litaoxmf@126.com E-mail:litaoxmf@126.com

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被引次数

1

摘要：  Bmi-1基因作为一种转录抑制因子，是多梳基因（polyeomb group gene）家族成员之一。可能在干细胞的自我更新与增殖活性起重要作用。目前发现Bmi-1基因在多种实体肿瘤中存在高表达，可看做为肿瘤干细胞标志物之一，并与肿瘤的发生发展及放射抵抗有密切关系，可为恶性肿瘤的治疗提供重要的靶基因。

关键词:  肿瘤干细胞, 放射疗法, Bmi-1基因

Abstract: As a transcriptional repressor, Bmi-1 is a member of polyeomb group gene family. It may play an important role in self-renewal ability and proliferation of stem cell. At present, studies show that Bmi-1 is highly expressed in a variety of solid tumors, which can be regarded as one of the markers of cancer stem cells and has a close relation to the cancer development and progression and radiation resistance. It will provide an important target gene for the treatment of malignant tumors.

Key words: Neoplastic stem cells, Radiotherapy, Bmi-1 gene