国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (3): 187-190.

• 综述 • 上一篇    下一篇

动物侵袭模型在肿瘤中的相关研究

秦林, 岳文涛, 王子彤   

  1. 101149 首都医科大学附属北京胸科医院胸外科(秦林、王子彤);首都医科大学附属北京                              胸科医院结核病胸部肿瘤研究所细胞室(岳文涛)

  • 出版日期:2013-03-08 发布日期:2013-02-25
  • 通讯作者: 王子彤 E-mail:wztdoctor@163.com

Animal model of tumor invasion in cancer-related research

QIN  Lin, YUE  Wen-Tao, WANG  Zi-Tong   

  1. QIN Lin*, YUE Wen-tao, WANG Zi-tong. *Department of Thoracic Surgery, Affiliated Beijing Chest Hospital of Capital Medical University, Beijing 101149, China

  • Online:2013-03-08 Published:2013-02-25
  • Contact: WANG Zi-tong, E-mail: wztdoctor@163.com E-mail:wztdoctor@163.com

摘要: 肿瘤侵袭模型是研究肿瘤侵袭机制,评价肿瘤防治策略的重要工具。相对于体外模型,体内侵袭模型能更好的模拟肿瘤微环境以及肿瘤侵袭的生物学行为,通过肿瘤的形态学观察和侵袭相关蛋白的检测可以对动物侵袭模型进行评估,现已广泛应用于肿瘤侵袭相关的基础临床研究。

关键词: 模型, 动物, 肿瘤侵润, 免疫组织化学

Abstract: Tumor invasion model is an important tool to study the mechanisms of tumor invasion and to evaluate prevention and treatment of cancer. Compared to the in vitro model, in vivo model can simulate the tumor microenvironment and tumor invasion biological behaviour better. Morphological observation and invasion-related protein detection can be used to evaluate the animal invasion model, which are widely used in basic and clinical research now.

Key words: Models, animal, Neoplasm invasiveness, Immunohistochemistry