国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 96-99.

• 综述 • 上一篇    下一篇

诱导性多能干细胞在肿瘤治疗中的应用

张致庆, 赵庆华   

  1. 200080 上海交通大学附属第一人民医院骨科
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 赵庆华，E-mail:sawboneszhao@163.com E-mail:sawboneszhao@163.com
  • 基金资助:

    上海交通大学“医工交叉研究基金”（YG2011MS28）

Applications of induced pluripotent stem cell in cancer therapy

ZHANG  Zhi-Qing, ZHAO  Qing-Hua   

  1. Department of Orthopaedic Surgery, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2013-02-08 Published:2013-01-25
  • Contact: Corresponding author: ZHAO Qing-hua, E-mail: sawboneszhao@163.com E-mail:sawboneszhao@163.com

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被引次数

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摘要： 诱导性多能干细胞（iPSC）是由分化成熟的体细胞在体外重编程获得的。它具有与胚胎干细胞(ESC)相似的无限自我更新能力和多向分化潜能，但不受免疫学和伦理学的约束且获取方便。患者特异性的iPSC是肿瘤治疗中建立疾病模型、药物研发、再生治疗、免疫治疗、细胞载体等的宝贵来源。目前，应用iPSC技术治疗肿瘤已取得一定进展。

关键词: 细胞分化, 肿瘤, 诱导性多潜能干细胞

Abstract: Induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells through reprogramming in vitro. Similarly to embryonic stem cells (ESCs), iPSC have the ability of unlimited self-renewal and multiple differentiation potential. But they are without the constraints of immunology and ethics and acquire conveniently. Patient-specific iPSC provide an invaluable resource for disease modeling, drug discovery, regenerative therapy, immune therapy and cellular delivery vehicle in cancer therapy. Nowadays, the application of iPSC technology has made some progress in the treatment of tumors.

Key words: Cell differentation, Neoplasms, Induced pluripotent stem cells