国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (1): 12-15.

• 综述 • 上一篇    下一篇

孕激素相关子宫内膜蛋白基因与肿瘤

柴丽娜, 韩颖, 任素萍   

  1. 100850北京输血医学研究所二室(柴丽娜、韩颖、任素萍)；410083 中南大学湘雅医学院基础医学院(柴丽娜)
  • 出版日期:2013-01-08 发布日期:2013-01-15
  • 通讯作者: 任素萍，E-mail: rensp12@yahoo.com E-mail:rensp12@yahoo.com
  • 基金资助:

    国家自然科学基金（81071709）

Progestagen-associated endometrial protein gene and tumor

CHAI  Li-Na, HAN  Ying, REN  Su-Ping   

  1. Beijing Institute of Transfusion Medicine, Beijing 100850, China

  • Online:2013-01-08 Published:2013-01-15
  • Contact: Corresponding author: REN Su-ping, E-mail: rensp12@yahoo.com E-mail:rensp12@yahoo.com

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摘要： 孕激素相关子宫内膜蛋白（PAEP）基因是一个主要表达于分泌期子宫内膜和妊娠早期蜕膜的基因。近年来研究表明，PAEP基因在乳腺癌、子宫内膜癌、卵巢癌、胃癌、恶性黑素瘤等多种肿瘤组织中表达上调，对肿瘤发生发展起重要作用。要将PAEP基因作为临床诊断、判断预后及指导治疗的指标应用，还需进一步研究PAEP基因对肿瘤生物学行为影响的作用机制。

关键词: 肿瘤, 孕激素相关子宫内膜蛋白

Abstract: Progestagen-associated endometrial protein (PAEP) gene mainly expresses in the secretory phase endometrium and decidua in early trimester of pregnancy. In recent years, it is reported that PAEP is abnormally expressed in many kinds of tumors, such as breast cancer, endometrial carcinoma, ovary cancer, stomach cancer and melanoma. PAEP gene plays an important role in tumorigenesis and tumor development. The application of PAEP gene as an indicator for clinical diagnosis, prognostic and therapy needs further studies on the influence of PAEP gene on tumor biological behaviour.

Key words: Neoplasms, Progestagen-associated endometrial protein