国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 726-728.

• 综述 • 上一篇    下一篇

肿瘤细胞的糖酵解异常及靶向治疗

庞淯阳,王婷,陈芳源   

  1. 200127 上海交通大学附属仁济医院血液科
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 陈芳源，E-mail：chenfy04@yahoo.com.cn E-mail:chenfy04@yahoo.com.cn
  • 基金资助:

    国家自然科学基金资助项目（81172253）

Glycolysis abnormality in neoplasm cells and the targeted therapy

PANG  Yu-Yang, WANG  Ting, CHEN  Fang-Yuan   

  1. Department of Hematology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: CHEN Fang-yuan， E-mail: chenfy04@yahoo.com.cn E-mail:chenfy04@yahoo.com.cn

被引次数

6

摘要： 肿瘤细胞即使在供氧充足的条件下仍存在糖酵解途径的异常激活与线粒体呼吸受抑，以满足恶性增殖的需要。这一代谢表型的转变与肿瘤细胞线粒体功能缺陷、微环境缺氧状态、糖酵解途径上游调控因子的异常激活密切相关。针对肿瘤细胞糖酵解通路及其上游调控因子的靶向治疗有望为肿瘤治疗提供新的策略。  

关键词: 肿瘤, 糖酵解, 治疗

Abstract: Cancer cells display a decreased mitochondrial respiration along with an abnormal activation of glycolysis to satisfy the demand of the malignant growth even in the presence of oxygen. This phenomenon may be caused by mitochondrial dysfunction, hypoxia of microenvironment and the abnormal activation of upstream regulators of glycolysis pathway. Treatment targeted at the glycolysis pathway and its upstream regulators may provide a new therapeutic strategy of cancer.

Key words: Neoplasms, Glycolysis, Therapies