国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (7): 504-507.

• 综述 • 上一篇    下一篇

活性氧与肿瘤治疗

张厚莉,崔淑香   

  1. 济南，山东省医学科学院药物研究所药理室 济南大学山东省医学科学院医学与生命科学学院山东省罕少见病重点实验室
  • 出版日期:2012-08-06 发布日期:2012-08-06
  • 通讯作者: 崔淑香，E-mail: sxccui@sina.com E-mail:sxccui@sina.com
  • 基金资助:

    国家自然科学基金资助项目（81072665）

Reactive oxygen species and tumor therapy

ZHANG  Hou-Li, CUI  Shu-Xiang   

  1. Pharmacological Laboratory, Institute of Materia Medica, Shandong Academy of Medical Sciences, Medicine and Life Science, Jinan Univesity, Institute of Materia Medica,Shandong Academy of Medical Sciences.Key Laboratory for Rave Disease of Shandong Procince, Jinan 250062,  China
  • Online:2012-08-06 Published:2012-08-06
  • Contact: CUI Shu-xiang,E-mail: sxccui@sina.com E-mail:sxccui@sina.com

PDF

3056

被引次数

10

摘要： 氧化应激可以通过加速肿瘤细胞死亡达到肿瘤治疗的目的，作为机体发生氧化应激反应产生的主要分子，活性氧（ROS）主要通过促进细胞凋亡、细胞坏死以及自噬性细胞死亡发挥抗肿瘤作用。能够提高细胞内ROS水平的药物越来越受到人们的关注，这为肿瘤的临床治疗提供了新的研究方向。

关键词: 活性氧, 肿瘤, 治疗

Abstract: Oxidative stress can achieve the purpose of tumor therapy by accelerating the death of tumor cells. As a major molecule generated from the body's oxidative stress reaction, reactive oxygen species (ROS) exerts the antitumor efforts by promoting apoptosis, necrosis and autophagy. The drugs which could increase the level of ROS in cells have received more and more people's attention, and this provide a new research direction for the clinical treatment of tumors.

Key words: Reactive oxygen species, Neoplasms, Therapy