溶质载体SLC7A5及SLC7A11基因在恶性肿瘤中的研究进展

doi:10.3760/cma.j.cn371439-20230305-00056

摘要/Abstract

摘要：

溶质载体（SLC）作为氨基酸的转运渠道，存在于各类细胞上，其作用为转运各种氨基酸，为细胞的生长发育提供所需的营养物质。近年来发现的SLC7家族成员中的SLC7A5及SLC7A11基因在各类恶性肿瘤中存在高表达，通过为肿瘤提供所需的氨基酸，促进肿瘤的发生发展。研究显示，上述基因与多种恶性肿瘤均存在相关性，其表达与肿瘤细胞的生长、转移、治疗及预后密切相关。并且，多项研究结果提示SLC7A5及SLC7A11基因可作为恶性肿瘤的治疗靶点应用于靶向治疗。明确上述基因在恶性肿瘤中的表达及临床意义、分子生物学机制以及分子靶向治疗研究的进展，有助于为恶性肿瘤的诊断和治疗提供新的途径。

关键词: 溶质载体蛋白质类, 肿瘤, 基因表达, 分子生物学, 分子靶向治疗

Abstract:

As a transport channel for amino acids， solute carrier （SLC） exists in all kinds of cells， and its function is to transport various amino acids and provide necessary nutrients for the growth and development of cells. In recent years， SLC7A5 and SLC7A11 genes of SLC7 family members have been found to be highly expressed in various malignant tumors， which can promote the occurrence and development of tumors by providing necessary amino acids for tumors. Studies have shown that these genes are associated with a variety of malignant tumors， and their expression is closely related to the growth， metastasis， treatment and prognosis of tumor cells. Moreover， the results of multiple studies suggest that SLC7A5 and SLC7A11 genes can be used as therapeutic targets for malignant tumors. Clarifying the expression and clinical significance of the above genes in malignant tumors， the molecular biological mechanism and the progress of molecular targeted therapy are helpful to provide a new way for the diagnosis and treatment of malignant tumors.

Key words: Solute carrier proteins, Neoplasms, Gene expression, Molecular biology, Molecular targeted therapy

刘博翰, 黄俊星. 溶质载体SLC7A5及SLC7A11基因在恶性肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(5): 280-284.

Liu Bohan, Huang Junxing. Research progress of solute carriers related genes in malignant tumors[J]. Journal of International Oncology, 2023, 50(5): 280-284.

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