癌相关成纤维细胞在肿瘤放疗抵抗中的研究进展

doi:10.3760/cma.j.cn371439-20230105-00044

摘要/Abstract

摘要：

癌相关成纤维细胞（CAF）是肿瘤放疗效果严重受限的关键因素。CAF作为肿瘤微环境中的主要基质细胞，可通过分泌促肿瘤细胞因子和营养物质、抑制抗肿瘤免疫反应和重塑细胞外基质等导致肿瘤放疗抵抗。靶向CAF增敏放疗的研究已取得一定进展，但相关研究体系仍不完善。因此，系统探讨CAF在肿瘤放疗抵抗中的作用及其靶向治疗策略，可为改善肿瘤放疗抵抗现状提供依据。

关键词: 肿瘤, 放射疗法, 癌相关成纤维细胞, 肿瘤微环境

Abstract:

Cancer-associated fibroblasts （CAFs） is considered as a key factor for the severely limited efficacy in tumor radiotherapy. CAFs， as the primary stromal cells in the tumor microenvironment， can lead to tumor radiotherapy resistance by secreting a series of pro-tumor cytokines and nutrients， inhibiting anti-tumor immune response and remodeling extracellular matrix. Some progress has been made in the study of targeted CAFs sensitization radiotherapy，but the relevant study system is still imperfect. Therefore， a systematic exploration of the role of CAFs in tumor radiotherapy resistance and CAFs targeted therapy strategies can provide a basis for improving the current status of tumor radiotherapy resistance.

Key words: Neoplasms, Radiotherapy, Cancer-associated fibroblast, Tumor microenvironment

许萌, 姜伟, 朱海涛, 曹雄锋. 癌相关成纤维细胞在肿瘤放疗抵抗中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 227-230.

Xu Meng, Jiang Wei, Zhu Haitao, Cao Xiongfeng. Research progress of cancer-associated fibroblasts in tumor radiotherapy resistance[J]. Journal of International Oncology, 2023, 50(4): 227-230.

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