E2F1与lncRNA在恶性肿瘤发生发展中的作用

doi:10.3760/cma.j.cn371439-20221123-00032

国际肿瘤学杂志 ›› 2023, Vol. 50 ›› Issue (3): 164-168.doi: 10.3760/cma.j.cn371439-20221123-00032

E2F1与lncRNA在恶性肿瘤发生发展中的作用

拜莹¹, 李琦¹, 李亚芹², 赵卫红³()

¹山西医科大学第二临床医学院，太原 030001
²北京大学人民医院妇产科，北京 100044
³山西医科大学第二医院妇产科，太原 030001

收稿日期:2022-11-23 修回日期:2022-12-22 出版日期:2023-03-08 发布日期:2023-04-12
通讯作者: 赵卫红，Email： sydeyzwh@sxmu.edu.cn
基金资助:
国家自然科学基金(81702583);中国博士后科学基金(2019M651072);山西省应用基础研究计划(201901D211506);山西省回国留学人员科研资助项目(2022-195)

Role of E2F1 and lncRNAs in the development of malignant tumors

Bai Ying¹, Li Qi¹, Li Yaqin², Zhao Weihong³()

¹Second Clinical Medical College of Shanxi Medical University， Taiyuan 030001， China
²Department of Obstetrics and Gynecology， People's Hospital of Peking University， Beijing 100044， China
³Department of Obstetrics and Gynecology， Second Hospital of Shanxi Medical University， Taiyuan 030001， China

Received:2022-11-23 Revised:2022-12-22 Online:2023-03-08 Published:2023-04-12
Contact: Zhao Weihong， Email： sydeyzwh@sxmu.edu.cn
Supported by:
National Natural Science Foundation of China(81702583);China Postdoctoral Science Foundation(2019M651072);Shanxi Province Applied Basic Research Program(201901D211506);Research Project Supported by Shanxi Scholarship Council of China(2022-195)

摘要/Abstract

摘要：

E2F1作为转录因子类的核蛋白基因，与恶性肿瘤发生发展密切相关。长非编码RNA（lncRNA）在多种肿瘤中存在异常表达。在lncRNA与肿瘤相关分子机制研究中，E2F1是一个关键的因子，可作为lncRNA的上游调控因子或下游靶标发挥作用，甚至可以互为调控形成正反馈环。进一步研究E2F1与lncRNA在恶性肿瘤发生发展中的作用，可为肿瘤机制研究提供思路。

关键词: 肿瘤, RNA, 长链非编码, E2F1转录因子

Abstract:

E2F1， a nucleoprotein gene belongs to transcription factor， is closely associated with the development of malignant tumours. Long non-coding RNAs （lncRNAs） are aberrantly expressed in a variety of tumors. In studies of molecular mechanisms associated with lncRNAs and tumours， E2F1 has been identified as a key factor that can play a critical role as an upstream regulator or downstream target of lncRNAs， and even inter-regulate to form a positive feedback loop. This paper reviews the significance of the interaction between E2F1 and lncRNA in malignant tumors in recent years， and aims to provide ideas for the study of tumor mechanisms.

Key words: Neoplasms, RNA, long noncoding, E2F1 transcription factor

拜莹, 李琦, 李亚芹, 赵卫红. E2F1与lncRNA在恶性肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2023, 50(3): 164-168.

Bai Ying, Li Qi, Li Yaqin, Zhao Weihong. Role of E2F1 and lncRNAs in the development of malignant tumors[J]. Journal of International Oncology, 2023, 50(3): 164-168.

参考文献 41

[1]	Denechaud PD, Fajas L, Giralt A. E2F1, a novel regulator of metabolism[J]. Front Endocrinol (Lausanne), 2017, 8: 311. DOI: 10.3389/fendo.2017.00311. doi: 10.3389/fendo.2017.00311
[2]	Dubrez L. Regulation of E2F1 transcription factor by ubiquitin conjugation[J]. Int J Mol Sci, 2017, 18(10): 2188. DOI: 10.3390/ijms18102188. doi: 10.3390/ijms18102188
[3]	Goodall GJ, Wickramasinghe VO. RNA in cancer[J]. Nat Rev Cancer, 2021, 21(1): 22-36. DOI: 10.1038/s41568-020-00306-0. doi: 10.1038/s41568-020-00306-0 pmid: 33082563
[4]	Barbieri I, Kouzarides T. Role of RNA modifications in cancer[J]. Nat Rev Cancer, 2020, 20(6): 303-322. DOI: 10.1038/s41568-020-0253-2. doi: 10.1038/s41568-020-0253-2 pmid: 32300195
[5]	Qiu L, Ma Y, Yang Y, et al. Pro-angiogenic and pro-inflammatory regulation by lncRNA MCM3AP-AS1-mediated upregulation of DPP4 in clear cell renal cell carcinoma[J]. Front Oncol, 2020, 10: 705. DOI: 10.3389/fonc.2020.00705. doi: 10.3389/fonc.2020.00705 pmid: 32714856
[6]	Yuan L, Tian X, Zhang Y, et al. LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3[J]. Exp Mol Med, 2021, 53(8): 1218-1228. DOI: 10.1038/s12276-021-00647-2. doi: 10.1038/s12276-021-00647-2 pmid: 34408262
[7]	Kang J, Huang X, Dong W, et al. Long non-coding RNA LINC00630 facilitates hepatocellular carcinoma progression through recruiting transcription factor E2F1 to up-regulate cyclin-dependent kinase 2 expression[J]. Hum Exp Toxicol, 2021, 40(12_suppl): S257-S268. DOI: 10.1177/09603271211038744. doi: 10.1177/09603271211038744
[8]	Yu L, Fang F, Lu S, et al. lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1[J]. Cancer Gene Ther, 2017, 24(5): 221-226. DOI: 10.1038/cgt.2017.10. doi: 10.1038/cgt.2017.10 pmid: 28429752
[9]	Xin R, Hu B, Qu D, et al. Oncogenic lncRNA MALAT-1 recruits E2F1 to upregulate RAD51 expression and thus promotes cell autophagy and tumor growth in non-small cell lung cancer[J/OL]. Pulm Pharmacol The. [2023-01-20]. https://pubmed.ncbi.nlm.nih.gov/36690318/. DOI: 10.1016/j.pupt.2023.102199. doi: 10.1016/j.pupt.2023.102199
[10]	Luo J, Wang H, Wang L, et al. lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1[J]. Mol Ther Nucleic Acids, 2021, 25: 11-24. DOI: 10.1016/j.omtn.2021.04.022. doi: 10.1016/j.omtn.2021.04.022
[11]	Guo X, Chen Z, Zhao L, et al. Long non-coding RNA-HAGLR suppressed tumor growth of lung adenocarcinoma through epigenetically silencing E2F1[J]. Exp Cell Res, 2019, 382(1): 111461. DOI: 10.1016/j.yexcr.2019.06.006. doi: 10.1016/j.yexcr.2019.06.006
[12]	Mu B, Lv C, Liu Q, et al. Long non-coding RNA ZEB1-AS1 promotes proliferation and metastasis of hepatocellular carcinoma cells by targeting miR-299-3p/E2F1 axis[J]. J Biochem, 2021, 170(1): 41-50. DOI: 10.1093/jb/mvab042. doi: 10.1093/jb/mvab042
[13]	Li SY, Zhu Y, Li RN, et al. LncRNA Lnc-APUE is repressed by HNF4 α and promotes G1/S phase transition and tumor growth by regulating miR-20b/E2F1 axis[J]. Adv Sci (Weinh), 2021, 8(7): 2003094.
[14]	Zha W, Li X, Tie X, et al. The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma[J]. Sci Rep, 2021, 11(1): 805. DOI: 10.1038/s41598-020-80817-w. doi: 10.1038/s41598-020-80817-w pmid: 33436941
[15]	Lv X, Lian Y, Liu Z, et al. Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis[J]. Aging (Albany NY), 2021, 13(4): 6010-6024. DOI: 10.18632/aging.202522. doi: 10.18632/aging.202522
[16]	Meng Q, Liu M, Cheng R. LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration[J]. Biosci Rep, 2020, 40(2): BSR20191345. DOI: 10.1042/BSR20191345. doi: 10.1042/BSR20191345
[17]	Wu H, Zhou S, Zheng Y, et al. LncRNA BBOX1-AS1 promotes pituitary adenoma progression via sponging miR-361-3p/E2F1 axis[J]. Anticancer Drugs, 2022, 33(7): 652-662. DOI: 10.1097/CAD.0000000000001309. doi: 10.1097/CAD.0000000000001309
[18]	He H, Wang N, Yi X, et al. Long non-coding RNA H19 regulates E2F1 expression by competitively sponging endogenous miR-29a-3p in clear cell renal cell carcinoma[J]. Cell Biosci, 2017, 7: 65. DOI: 10.1186/s13578-017-0193-z. doi: 10.1186/s13578-017-0193-z pmid: 29214011
[19]	Wang X, Nie P, Zhu D. LncRNA HOXA10-AS activated by E2F1 facilitates proliferation and migration of nasopharyngeal carcinoma cells through sponging miR-582-3p to upregulate RAB31[J]. Am J Rhinol Allergy, 2022, 36(3): 348-359. DOI: 10.1177/19458 924211064400. doi: 10.1177/19458924211064400
[20]	Lu G, Li Y, Ma Y, et al. Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis[J]. J Exp Clin Cancer Res, 2018, 37(1): 289. DOI: 10.1186/s13046-018-0945-6. doi: 10.1186/s13046-018-0945-6
[21]	Chen B, Zhao Q, Guan L, et al. Long non-coding RNA NNT-AS1 sponges miR-424/E2F1 to promote the tumorigenesis and cell cycle progression of gastric cancer[J]. J Cell Mol Med, 2018, 22(10): 4751-4759. DOI: 10.1111/jcmm.13726. doi: 10.1111/jcmm.13726 pmid: 30006956
[22]	Yang BY, Meng Q, Sun Y, et al. Long non-coding RNA SNHG16 contributes to glioma malignancy by competitively binding miR-20a-5p with E2F1[J]. J Biol Regul Homeost Agents, 2018, 32(2): 251-261.
[23]	Li X, Zhang H, Wu X. Long noncoding RNA DLX6-AS1 accelerates the glioma carcinogenesis by competing endogenous sponging miR-197-5p to relieve E2F1[J]. Gene, 2019, 686: 1-7. DOI: 10.1016/j.gene.2018.10.065. doi: S0378-1119(18)31104-1 pmid: 30366080
[24]	Kang Y, Wan L, Wang Q, et al. Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer[J]. Cell Biosci, 2021, 11(1): 169. DOI: 10.1186/s13578-021-00675-5. doi: 10.1186/s13578-021-00675-5 pmid: 34465388
[25]	Yang Y, Ge H, Li DQ, et al. E2F1-induced lncRNA BAIAP2-AS1 overexpression contributes to the malignant progression of hepatocellular carcinoma via miR-361-3p/SOX4 axis[J]. Dis Markers, 2021, 2021: 6256369. DOI: 10.1155/2021/6256369. doi: 10.1155/2021/6256369
[26]	Ye Y, Gu B, Wang Y, et al. E2F1-mediated MNX1-AS1-miR-218-5p-SEC61A1 feedback loop contributes to the progression of colon adenocarcinoma[J]. J Cell Biochem, 2019, 120(4): 6145-6153. DOI: 10.1002/jcb.27902. doi: 10.1002/jcb.27902 pmid: 30362161
[27]	Zhou X, Li J, Teng J, et al. Long noncoding RNA BSN-AS2 induced by E2F1 promotes spinal osteosarcoma progression by targeting miR-654-3p/SYTL2 axis[J]. Cancer Cell Int, 2020, 20: 133. DOI: 10.1186/s12935-020-01205-y. doi: 10.1186/s12935-020-01205-y pmid: 32351327
[28]	Zhao H, Xu Q. Long non-coding RNA DLX6-AS1 mediates proli-feration, invasion and apoptosis of endometrial cancer cells by recruiting p300/E2F1 in DLX6 promoter regionn[J]. J Cell Mol Med, 2020, 24(21): 12572-12584. DOI: 10.1111/jcmm.15810. doi: 10.1111/jcmm.15810
[29]	Zhao L, Zheng Y, Zhang L, et al. E2F1-induced FTH1P3 promoted cell viability and glycolysis through miR-377-3p/LDHA axis in laryngeal squamous cell carcinoma[J]. Cancer Biother Radiopharm, 2022, 37(4): 276-286. DOI: 10.1089/cbr.2020.4266. doi: 10.1089/cbr.2020.4266
[30]	Shi J, Li J, Yang S, et al. LncRNA SNHG3 is activated by E2F1 and promotes proliferation and migration of non-small-cell lung cancer cells through activating TGF-β pathway and IL-6/JAK2/STAT3 pathway[J]. J Cell Physiol, 2020, 235(3): 2891-2900. DOI: 10.1002/jcp.29194. doi: 10.1002/jcp.29194 pmid: 31602642
[31]	Li H, Chen YK, Wan Q, et al. Long non-coding RNA LINC00847 induced by E2F1 accelerates non-small cell lung cancer progression through targeting miR-147a/IFITM1 axis[J]. Front Med (Lausanne), 2021, 8: 663558. DOI: 10.3389/fmed.2021.663558. doi: 10.3389/fmed.2021.663558
[32]	Wang A, Wang J. E2F1-induced overexpression of long noncoding RNA SBF2-AS1 promotes non-small-cell lung cancer metastasis through regulating miR-362-3p/GRB2 axis[J]. DNA Cell Biol, 2020, 39(7): 1290-1298. DOI: 10.1089/dna.2020.5426. doi: 10.1089/dna.2020.5426 pmid: 32364763
[33]	Zheng G, Chen W, Li W, et al. E2F1-induced ferritin heavy chain 1 pseudogene 3 (FTH1P3) accelerates non-small cell lung cancer gefitinib resistance[J]. Biochem Biophys Res Commun, 2020, 530(4): 624-631. DOI: 10.1016/j.bbrc.2020.07.044. doi: 10.1016/j.bbrc.2020.07.044
[34]	Fu D, Zhang Y, Cui H. Long noncoding RNA CCAT2 is activated by E2F1 and exerts oncogenic properties by interacting with PTTG1 in pituitary adenomas[J]. Am J Cancer Res, 2018, 8(2): 245-255. pmid: 29511595
[35]	Yu J, Zhang B, Zhang H, et al. E2F1-induced upregulation of long non-coding RNA LMCD1-AS1 facilitates cholangiocarcinoma cell progression by regulating miR-345-5p/COL6A3 pathway[J]. Biochem Biophys Res Commun, 2019, 512(2): 150-155. DOI: 10.1016/j.bbrc.2019.03.054. doi: 10.1016/j.bbrc.2019.03.054
[36]	Zhang Z, Li SY, Zhang LB. LncRNA RGMB-AS1 is activated by E2F1 and promotes cell proliferation and invasion in papillary thyroid carcinoma[J]. Eur Rev Med Pharmacol Sci, 2018, 22(7): 1979-1986. DOI: 10.26355/eurrev_201804_14725. doi: 10.26355/eurrev_201804_14725
[37]	Qi P, Lin WR, Zhang M, et al. E2F1 induces LSINCT5 transcriptional activity and promotes gastric cancer progression by affecting the epithelial-mesenchymal transition[J]. Cancer Manag Res, 2018, 10: 2563-2571. DOI: 10.2147/CMAR.S171652. doi: 10.2147/CMAR.S171652 pmid: 30127643
[38]	Xi J, Feng J, Zeng S, et al. Long noncoding RNA UFC1 is activated by E2F1 and exerts oncogenic properties by functioning as a ceRNA of FOXP3[J]. Cancer Med, 2018, 7(7): 3301-3310. DOI: 10.1002/cam4.1556. doi: 10.1002/cam4.1556
[39]	Logotheti S, Marquardt S, Gupta SK, et al. LncRNA-SLC16A1-AS1 induces metabolic reprogramming during bladder cancer progression as target and co-activator of E2F1[J]. Theranostics, 2020, 10(21): 9620-9643. DOI: 10.7150/thno.44176. doi: 10.7150/thno.44176 pmid: 32863950
[40]	Wang H, Yu S, Peng H, et al. Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma[J]. J Exp Clin Cancer Res, 2020, 39(1): 216. DOI: 10.1186/s13046-020-01725-5. doi: 10.1186/s13046-020-01725-5
[41]	Ren X, Chen C, Luo Y, et al. lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer[J]. Mol Cancer, 2020, 19(1): 35. DOI: 10.1186/s12943-020-01153-1. doi: 10.1186/s12943-020-01153-1 pmid: 32085715

E2F1与lncRNA在恶性肿瘤发生发展中的作用

Role of E2F1 and lncRNAs in the development of malignant tumors

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