国际肿瘤学杂志 ›› 2022, Vol. 49 ›› Issue (4): 243-246.doi: 10.3760/cma.j.cn371439-20220208-00044

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放疗联合免疫治疗在乳腺癌脑转移瘤中的潜在价值

孙晓琳1, 张展昱1, 许林宗1, 刘英超2, 李晓梅1()   

  1. 1山东大学附属省立医院肿瘤治疗中心,济南 250021
    2山东第一医科大学附属省立医院神经外科,济南 250021
  • 收稿日期:2022-02-08 修回日期:2022-03-03 出版日期:2022-04-08 发布日期:2022-05-11
  • 通讯作者: 李晓梅 E-mail:sdulixiaomei@163.com

Potential value of radiotherapy combined with immunotherapy in breast cancer brain metastases

Sun Xiaolin1, Zhang Zhanyu1, Xu Linzong1, Liu Yingchao2, Li Xiaomei1()   

  1. 1Tumor Research and Therapy Center, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, China
    2Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
  • Received:2022-02-08 Revised:2022-03-03 Online:2022-04-08 Published:2022-05-11
  • Contact: Li Xiaomei E-mail:sdulixiaomei@163.com

摘要:

随着对脑内独特的免疫微环境的认识和了解的不断增加,免疫治疗已经成为治疗脑转移瘤的一种新的、有前景的治疗方案。放疗与免疫治疗具有协同作用,深入了解其在乳腺癌脑转移瘤中的作用机制,对指导乳腺癌脑转移瘤的治疗具有重要价值。目前免疫检查点抑制剂联合放疗在乳腺癌脑转移瘤的研究正在积极开展,为乳腺癌脑转移瘤患者带来了新的希望。

关键词: 乳腺肿瘤, 脑转移, 免疫检查点抑制剂, 放射治疗

Abstract:

With the increasing understanding of the unique tumor microenvironment in the brain, immunotherapy have emerged as a new and promising treatment for brain metastases. Radiotherapy and immunotherapy have a synergistic effect, and it is of great value to understand its mechanism in the treatment of breast cancer brain metastases. At present, the study of immune checkpoint inhibitors combined with radiotherapy in breast cancer brain metastases is being actively carried out, bringing new hope to patients with breast cancer brain metastases.

Key words: Breast neoplasms, Brain metastases, Immune checkpoint inhibitors, Radiotherapy