三氧化二砷抗肝癌机制及其在肝癌治疗中的研究

doi:10.3760/cma.j.cn371439-20201201-00112

摘要/Abstract

摘要：

三氧化二砷(ATO)参与肝癌细胞的多种生物学过程,包括肿瘤细胞凋亡诱导、增殖抑制、侵袭转移抑制和肿瘤干细胞抑制等。ATO在肝癌治疗中有多种方式,主要包括单药治疗、联合局部治疗、联合全身治疗等。进一步研究ATO抗癌机制及临床应用有望为肝癌治疗提供新的思路。

关键词: 肝肿瘤, 治疗应用, 三氧化二砷

Abstract:

Arsenic trioxide (ATO) is involved in a variety of biological processes of hepatocellular carcinoma (HCC) cells, including apoptosis induction, proliferation inhibition, invasion and metastasis inhibition, and tumor stem cell inhibition. ATO has a variety of therapeutic approaches in the treatment of HCC, mainly including single drug therapy, combined local therapy, combined systemic therapy, and so on. Further research on the anti-cancer mechanism and clinical application of ATO is expected to provide new ideas for the treatment of liver cancer.

Key words: Liver neoplasms, Therapeutic uses, Arsenic trioxide

杜佳航, 陈栋, 陈耀庭. 三氧化二砷抗肝癌机制及其在肝癌治疗中的研究[J]. 国际肿瘤学杂志, 2021, 48(9): 572-.

Du Jiahang, Chen Dong, Chen Yaoting. Research progress of arsenic trioxide in anti-liver cancer mechanism and treatment of hepatocellular carcinoma[J]. Journal of International Oncology, 2021, 48(9): 572-.

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