预防性全脑照射引起小细胞肺癌患者脑损伤的研究进展

doi:10.3760/cma.j.cn371439-20201207-00111

摘要/Abstract

摘要：

小细胞肺癌(SCLC)是肺癌中恶性程度较高的病理类型,早期易发生脑转移。预防性全脑照射(PCI)可以降低SCLC患者脑转移的风险,但PCI导致脑结构及功能损伤发生率较高,其临床症状不典型。现有治疗方法虽然能缓解部分临床症状,但无法有效逆转脑损伤过程,导致患者的生存获益下降。深入了解PCI神经毒性的发生机制,探索预防及治疗的有效策略,对改善SCLC预后有重要价值。

关键词: 小细胞肺癌, 脑损伤, 认知功能障碍, 预防性全脑照射

Abstract:

Small cell lung cancer (SCLC), as a pathological type with high malignancy, presents a high risk of early brain metastasis. Prophylactic cranial irradiation (PCI) can reduce the risk of brain metastasis in patients with SCLC, however, the incidence of brain structural and functional damage caused by PCI is high, and their clinical symptoms are not typical. The existing treatment methods can relieve some clinical symptoms, but can not effectively reverse the process of brain injury, which reduces the survival benefit of patients. In-depth understanding the mechanisms of PCI neurotoxicity and exploring effective strategies for ptevention and treatment are of great value in improving prognosis of SCLC.

Key words: Small cell lung carcinoma, Brain injuries, Cognitive dysfunction, Prophylactic cranial irradiation

张红娥, 周清华, 刘洁薇, 代爽, 周洁. 预防性全脑照射引起小细胞肺癌患者脑损伤的研究进展[J]. 国际肿瘤学杂志, 2021, 48(9): 568-571.

Zhang Hong'e, Zhou Qinghua, Liu Jiewei, Dai Shuang, Zhou Jie. Research progress of brain injuries in patients with small cell lung cancer caused by prophylactic cranial irradiation[J]. Journal of International Oncology, 2021, 48(9): 568-571.

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