恶性肿瘤中BCL9的功能及其靶向治疗研究

doi:10.3760/cma.j.cn371439-20200224-00048

摘要/Abstract

摘要：

在肿瘤的发生发展中,经典Wnt/β-catenin信号通路发挥着重要作用,是抗肿瘤治疗的潜在靶点,然而该通路也参与调节正常组织的再生,因此通路靶向抑制剂的专一性受到影响。β-catenin的共激活因子B细胞淋巴瘤因子9(BCL9)仅在肿瘤细胞中高表达,因此靶向β-catenin与BCL9相互作用的抑制剂可能有更好的特异性和安全性。BCL9通过诱导肿瘤细胞上皮间质转化、上调血管内皮生长因子和CD44的基因表达、调节肿瘤干细胞特性来促进肿瘤的生长、浸润和转移,有望成为抗肿瘤治疗的新靶点。

关键词: Wnt信号通路, 肿瘤, 分子靶向治疗

Abstract:

Canonical Wnt/β-catenin signaling pathway is of great significance to the occurrence and progression of tumors which make it an exciting target in cancer therapy. The pathway is also required in regeneration of normal tissues, so the specificity of inhibitors targeting this pathway may be affected. The coactivator of β-catenin, B cell lymphoma 9 (BCL9), is highly expressed merely in tumor cells. Accordingly, inhibitors targeting the interaction between β-catenin and BCL9 may demonstrate robust specificity and minimal toxicity. BCL9 increases tumor growth, invasion and metastasis by promoting epithelial-mesenchymal transition, up-regulating vascular endothelial growth factor and CD44 expression and regulating cancer stem cell traits. BCL9 promises to be a new target for cancer therapy.

Key words: Wnt signaling pathway, Neoplasms, Molecular targeted therapy

翟婧彤, 马飞. 恶性肿瘤中BCL9的功能及其靶向治疗研究[J]. 国际肿瘤学杂志, 2020, 47(7): 419-422.

Zhai Jingtong, Ma Fei. Research on the function and targeted therapy of BCL9 in malignant tumors[J]. Journal of International Oncology, 2020, 47(7): 419-422.

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