Bub1及其在肿瘤中的研究进展

doi:10.3760/cma.j.cn371439-20200113-00020

摘要/Abstract

摘要：

Bub1通过参与组装纺锤体组装检查点(SAC)以保证姐妹染色单体正确分离。Bub1异常表达可导致SAC功能缺陷,增加染色体不稳定性及非整倍体细胞的发生率。近年来研究发现Bub1在多种恶性肿瘤中呈异常表达,并通过影响肿瘤细胞增殖、侵袭、迁移及肿瘤干细胞活性等参与恶性肿瘤发生发展。进一步了解Bub1在恶性肿瘤中的作用机制有望为肿瘤靶向治疗提供新方法。

关键词: 肿瘤, Bub1

Abstract:

Bub1 is essential for assembling of the functional spindle assembly checkpoint (SAC) to guarantee the correct separation of sister chromatids. Abnormal expression of Bub1 can elevate defects in SAC function, chromosome instability, and the incidence of aneuploidy. Several recent studies indicate that aberrantly expressed Bub1 may promote the tumorigenesis via regulating cell proliferation, invasion, migration and cancer stem cell activation. Further understanding of the mechanism of Bub1 in malignancy may provide new targeted therapy strategies.

Key words: Neoplasms, Bub1

王梦妮, 吕卫国. Bub1及其在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2020, 47(5): 289-292.

Wang Mengni, Lyu Weiguo. Research progress of Bub1 in cancers[J]. Journal of International Oncology, 2020, 47(5): 289-292.

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