微小RNA-125b与肿瘤

doi:10.3760/cma.j.issn.1673-422X.2020.02.005

国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (2): 90-92.doi: 10.3760/cma.j.issn.1673-422X.2020.02.005

微小RNA-125b与肿瘤

刘乾乾¹, 何小兰², 唐林¹, 袁艺箫¹, 邱顺¹, 段林灿¹()

1 昆明医科大学第三附属医院(云南省肿瘤医院)胸外科 650118
2 昆明医科大学护理学院650500

收稿日期:2019-10-21 修回日期:2019-11-21 出版日期:2020-02-08 发布日期:2020-05-27
通讯作者: 段林灿 E-mail:duanmumuhuosan@163.com
基金资助:
国家自然科学基金(81960426);云南省高层次卫生计生技术人才培养专项(D-201614)

MicroRNA-125b and cancer

Liu Qianqian¹, He Xiaolan², Tang Lin¹, Yuan Yixiao¹, Qiu Shun¹, Duan Lincan¹()

1 Department of Thoracic Surgery, Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming 650118, China
2 Nursing School of Kunming Medical University, Kunming 650500, China

Received:2019-10-21 Revised:2019-11-21 Online:2020-02-08 Published:2020-05-27
Contact: Duan Lincan E-mail:duanmumuhuosan@163.com
Supported by:
National Natural Science Foundation of China(81960426);High Level Health and Family Planning Technical Personnel Training Fund of Yunnan Province of China(D-201614)

摘要/Abstract

摘要：

微小RNA-125b(miR-125b)近年来被证明与多种肿瘤疾病关系密切,如肺癌、消化系统肿瘤、血液系统肿瘤等。miR-125b在肿瘤疾病的发生发展中起关键性作用,检测miR-125b的表达量可以评估各种肿瘤疾病治疗方式的疗效,并能辅助诊断肿瘤。探索miR-125b在肿瘤疾病中的机制对肿瘤治疗具有重大意义。

关键词: 微RNAs, 肿瘤, 诊断, 预后, miR-125b

Abstract:

MicroRNA-125b (miR-125b) has been proved to be closely related to a variety of cancers in recent years, such as lung cancer, digestive system cancers, blood cancers, etc. miR-125b plays a key role in the occurrence and development of cancers, which can evaluate the therapeutic effects of various treatment methods of cancers by detecting the expression of miR-125b, and can assist in the diagnosis of cancers. It is of great significance to explore the mechanism of miR-125b in cancers for the treatment.

Key words: MicroRNAs, Neoplasms, Diagnosis, Prognosis, miR-125b

刘乾乾, 何小兰, 唐林, 袁艺箫, 邱顺, 段林灿. 微小RNA-125b与肿瘤[J]. 国际肿瘤学杂志, 2020, 47(2): 90-92.

Liu Qianqian, He Xiaolan, Tang Lin, Yuan Yixiao, Qiu Shun, Duan Lincan. MicroRNA-125b and cancer[J]. Journal of International Oncology, 2020, 47(2): 90-92.

参考文献 20

[1]	Yin H, Sun Y, Wang X , et al. Progress on the relationship between miR-125 family and tumorigenesis[J]. Exp Cell Res, 2015,339(2):252-260. DOI: 10.1016/j.yexcr.2015.09.015.
[2]	Tang XY, Zheng W, Ding M , et al. miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism[J]. Drug Des Devel Ther, 2016,10:571-583. DOI: 10.2147/DDDT.S90530.
[3]	Jin XJ, Chen XJ, Zhang ZF , et al. Long noncoding RNA SNHG12 promotes the progression of cervical cancer via modulating miR-125b/STAT3 axis[J]. J Cell Physiol, 2019,234(5):6624-6632. DOI: 10.1002/jcp.27403. doi: 10.1002/jcp.27403
[4]	Biamonte F, Battaglia AM, Zolea F , et al. Ferritin heavy subunit enhances apoptosis of non-small cell lung cancer cells through modulation of miR-125b/p53 axis[J]. Cell Death Dis, 2018,9(12):1174. DOI: 10.1038/s41419-018-1216-3.
[5]	Zhao A, Zeng Q, Xie X , et al. MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression[J]. J Genet Genomics, 2012,39(1):29-35. DOI: 10.1016/j.jgg.2011.12.003.
[6]	Ottaviani S, Castellano L . MicroRNAs: novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma[J]. Mol Cell Oncol, 2018,5(6):e1499066. DOI: 10.1080/23723556.2018.1499066.
[7]	Zhang J, Na S, Liu C , et al. MicroRNA-125b suppresses the epithelial-mesenchymal transition and cell invasion by targeting ITGA9 in melanoma[J]. Tumour Biol, 2016,37(5):5941-5949. DOI: 10.1007/s13277-015-4409-8.
[8]	Zhang X, Liu Y, Huang WC , et al. miR-125b-1-3p exerts antitumor functions in lung carcinoma cells by targeting S1PR1[J]. Chin Med J (Engl), 2018,131(16):1909-1916. DOI: 10.4103/0366-6999.238135.
[9]	Parayath NN, Parikh A, Amiji MM . Repolarization of tumor-associated macrophages in a genetically engineered nonsmall cell lung cancer model by intraperitoneal administration of hyaluronic acid-based nanoparticles encapsulating microRNA-125b[J]. Nano Lett, 2018,18(6):3571-3579. DOI: 10.1021/acs.nanolett.8b00689.
[10]	Wang Y, Zhao M, Liu J , et al. miRNA-125b regulates apoptosis of human non-small cell lung cancer via the PI3K/Akt/GSK3β signaling pathway[J]. Oncol Rep, 2017,38(3):1715-1723. DOI: 10.3892/or.2017.5808.
[11]	Riquelme I, Tapia O, Leal P , et al. miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway[J]. Cell Oncol (Dordr), 2016,39(1):23-33. DOI: 10.1007/s13402-015-0247-3.
[12]	Tanaka H, Hazama S, Iida M , et al. miR-125b-1 and miR-378a are predictive biomarkers for the efficacy of vaccine treatment against colorectal cancer[J]. Cancer Sci, 2017,108(11):2229-2238. DOI: 10.1111/cas.13390.
[13]	Zhu HR, Huang RZ, Yu XN , et al. Microarray expression profiling of microRNAs reveals potential biomarkers for hepatocellular carcinoma[J]. Tohoku J Exp Med, 2018,245(2):89-98. DOI: 10.1620/tjem.245.89.
[14]	Fan YX, Bian XH, Qian PD , et al. MicroRNA-125b inhibits cell proliferation and induces cell apoptosis in esophageal squamous cell carcinoma by targeting BMF[J]. Oncol Rep, 2018,40(1):61-72. DOI: 10.3892/or.2018.6413.
[15]	Wang Y, Tang P, Chen Y , et al. Overexpression of microRNA-125b inhibits human acute myeloid leukemia cells invasion, proliferation and promotes cells apoptosis by targeting NF-κB signaling pathway[J]. Biochem Biophys Res Commun, 2017,488(1):60-66. DOI: 10.1016/j.bbrc.2017.05.007.
[16]	Congras A, Caillet N, Torossian N , et al. Doxorubicin-induced loss of DNA topoisomerase Ⅱ and DNMT1- dependent suppression of miR-125b induces chemoresistance in ALK-positive cells[J]. Oncotarget, 2018,9(18):14539-14551. DOI: 10.18632/oncotarget.24465.
[17]	Piatopoulou D, Avgeris M, Marmarinos A , et al. miR-125b predicts childhood acute lymphoblastic leukaemia poor response to BFM chemotherapy treatment[J]. Br J Cancer, 2017,117(6):801-812. DOI: 10.1038/bjc.2017.256.
[18]	邓益民, 罗霭玲, 李广芬 , 等. 下调miR-125b逆转白血病细胞对多柔比星的耐药作用[J]. 中国实验血液学杂志, 2018,26(6):1610-1615. DOI: 10.7534/j.issn.1009-2137.2018.06.005.
[19]	Liu B, Su F, Chen M , et al. Serum miR-21 and miR-125b as markers predicting neoadjuvant chemotherapy response and prognosis in stage Ⅱ/Ⅲ breast cancer[J]. Hum Pathol, 2017,64:44-52. DOI: 10.1016/j.humpath.2017.03.016. doi: 10.1016/j.humpath.2017.03.016
[20]	Ahram M, Mustafa E, Zaza R , et al. Differential expression and androgen regulation of microRNAs and metalloprotease 13 in breast cancer cells[J]. Cell Biol Int, 2017,41(12):1345-1355. DOI: 10.1002/cbin.10841.

微小RNA-125b与肿瘤

MicroRNA-125b and cancer

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