外泌体miRNA作为乳腺癌生物标志物的临床应用

doi:10.3760/cma.j.issn.1673-422X.2019.07.007

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (7): 423-426.doi: 10.3760/cma.j.issn.1673-422X.2019.07.007

外泌体miRNA作为乳腺癌生物标志物的临床应用

曹黎霞，史振东，刘晶晶，张瑾

天津医科大学肿瘤医院乳腺三科国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室天津市恶性肿瘤临床医学研究中心300060

出版日期:2019-07-08 发布日期:2019-07-16
通讯作者: 张瑾 E-mail:zhangjin@tjmuch.com
基金资助:
国家自然科学基金（81502306、81672623）

Clinical application of exosomal miRNA as biomarker in breast cancer

Cao Lixia, Shi Zhendong, Liu Jingjing, Zhang Jin

Third Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Clinical Research Center for Cancer of Tianjin, Tianjin 300060, China

Online:2019-07-08 Published:2019-07-16
Contact: Zhang Jin E-mail:zhangjin@tjmuch.com
Supported by:
National Natural Science Foundation of China (81502306, 81672623)

摘要/Abstract

摘要： 微小RNA（miRNA）具有肿瘤特异性的表达谱，且在肿瘤发生和进展中发挥重要作用，其通过外泌体的包裹免受体液中核糖核酸酶的侵害，在乳腺癌细胞之间水平转移遗传信息。近年来针对外泌体miRNA的研究发现，其与乳腺癌的发生、诊治及预后关系密切。深入探讨这一领域的研究，可为外泌体miRNA作为乳腺癌生物标志物的临床应用提供理论依据。

关键词: 乳腺肿瘤, 外泌体, 微RNAs, 生物标志物

Abstract: MicroRNA (miRNA) has a tumorspecific expression profile and plays an important role in the occurrence and progression of tumors. It is protected from RNase in body fluids through the inclusion of exosomes and translocates genetic information horizontally between breast cancer cells. Recent studies on exosome miRNA have found that it is closely related to the occurrence, diagnosis, treatment and prognosis of breast cancer. The indepth study in this field can provide theoretical basis for the clinical application of exosome miRNA as a biomarker for breast cancer.

Key words: Breast neoplasms, Exosomes, MicroRNAs, Biomarker

曹黎霞，史振东，刘晶晶，张瑾. 外泌体miRNA作为乳腺癌生物标志物的临床应用[J]. 国际肿瘤学杂志, 2019, 46(7): 423-426.

Cao Lixia, Shi Zhendong, Liu Jingjing, Zhang Jin. Clinical application of exosomal miRNA as biomarker in breast cancer[J]. Journal of International Oncology, 2019, 46(7): 423-426.

参考文献

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外泌体miRNA作为乳腺癌生物标志物的临床应用

Clinical application of exosomal miRNA as biomarker in breast cancer

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