国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (6): 346-349.doi: 10.3760/cma.j.issn.1673-422X.2019.06.006

• 综述 • 上一篇    下一篇

lncRNA SNHG15在恶性肿瘤中的表达及其作用机制

李莹莹, 黄俊星   

  1. 南通大学医学院附属泰州市人民医院肿瘤科225300
  • 出版日期:2019-06-08 发布日期:2019-07-11
  • 通讯作者: 黄俊星，Email: hjxtz@163.com E-mail: hjxtz@163.com
  • 基金资助:

    江苏省医学创新团队项目（CXTDA2017042）

Expression and mechanisms of long non-coding RNAs SNHG15 in cancers

Li Yingying, Huang Junxing   

  1. Department of Oncology, Taizhou People′s Hospital Affiliated to Medical College of Nantong University, Taizhou 225300, China
  • Online:2019-06-08 Published:2019-07-11
  • Contact: Huang Junxing, Email: hjxtz@163.com E-mail: hjxtz@163.com
  • Supported by:

    Medical Innovation Team Project of Jiangsu Province of China (CXTDA2017042)

PDF

1909

摘要： 小核仁RNA宿主基因15（SNHG15）是长非编码RNA(lncRNA)的一种,定位于7号染色体。近年来有研究指出lncRNA SNHG15在多种恶性肿瘤如胶质瘤、甲状腺癌、乳腺癌、肺癌、胃癌、结直肠癌、肝癌、胰腺癌、肾癌、骨肉瘤中过表达，其可通过不同信号通路促进肿瘤细胞的增殖、侵袭、转移，并导致肿瘤患者预后不良。

关键词: RNA, 长链非编码, 肿瘤, 小核仁RNA宿主基因15

Abstract: As a kind of long non-coding RNAs (lncRNAs), small nucleolar RNA host gene 15 (SNHG15) is located on chromosome 7. In recent years, studies have shown that lncRNA SNHG15 is over expressed in various types of cancers such as glioma, thyroid cancer, breast cancer, lung cancer, gastric cancer, colorectal cancer, liver cancer, renal carcinoma, pancreatic cancer, osteosarcoma, and it can promote the proliferation, invasion, metastasis of malignant tumors and lead to poor prognosis of tumor patients through different signal pathways.

Key words: RNA, long noncoding, Neoplasms, Small nucleolar RNA host gene 15