HOXC基因在肿瘤中的作用

doi:10.3760/cma.j.issn.1673-422X.2019.03.011

摘要/Abstract

摘要： HOXC基因编码的蛋白在胚胎发育中调节多个过程，包括细胞的生长、分化、凋亡、运动和血管生成等，HOXC基因也参与人类多种实体肿瘤的发生、发展，如结直肠癌、胃癌、肝癌、乳腺癌、子宫内膜癌等，且与肿瘤的临床分期、远处转移密切相关，可作为肿瘤转移和预后判断的一个生物学预测因子。

关键词: 肿瘤, 基因, 同源盒, HOXC

Abstract: The protein encoded by the HOXC gene regulates multiple processes during embryonic development, including cell growth, differentiation, apoptosis, migration and angiogenesis. The HOXC gene is also involved in the occurrence and development of various human solid tumors, such as colorectal cancer, gastric cancer, liver cancer, breast cancer, endometrial cancer, etc. In addition, the HOXC gene is closely related to the clinical stage and distant metastasis of the tumor. Thus, the HOXC gene can be used as a biological predictor of tumor metastasis and prognosis.

Key words: Neoplasms, Genes, homeobox, HOXC

李竟长，倪秉强. HOXC基因在肿瘤中的作用[J]. 国际肿瘤学杂志, 2019, 46(3): 181-185.

Li Jingzhang, Ni Bingqiang. Roles of HOXC gene in tumors[J]. Journal of International Oncology, 2019, 46(3): 181-185.

参考文献

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