CRISPR/Cas9基因编辑技术及其在肿瘤治疗中的应用

doi:10.3760/cma.j.issn.1673-422X.2018.09.010

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (8): 556-560.doi: 10.3760/cma.j.issn.1673-422X.2018.09.010

CRISPR/Cas9基因编辑技术及其在肿瘤治疗中的应用

杨业环，杨成玮，谭小庆，高兴春

710021 西安医学院基础医学部陕西省脑疾病防治重点实验室

出版日期:2018-09-08 发布日期:2018-11-15
通讯作者: 高兴春 E-mail:gxc199281003@163.com
基金资助:
国家自然科学基金（81873740）；陕西省自然科学基金（2017JM8086）；西安医学院分子免疫学重点学科；陕西省优势学科建设经费资助项目；大学生创新创业训练计划项目(G201711840017)

CRISPR/Cas9 genome editing system and its application in tumor therapy

Yang Yehuan, Yang Chengwei, Tan Xiaoqing, Gao Xingchun

Institute of Basic Medical Sciences, Xi′an Medical University; Shaanxi Key Laboratory of Brain Disorders, Xi′an 710021, China

Online:2018-09-08 Published:2018-11-15
Contact: Gao Xingchun E-mail:gxc199281003@163.com
Supported by:
National Natural Science Foundation of China (81873740); Natural Science Foundation of Shaanxi Province of China (2017JM8086); Xi′an Medical University′s Key Disciplines of Molecular Immunology; Leading Disciplines Development Government Foundation of Shaanxi Province; College Students′ Innovation and Entrepreneurship Training Program (G201711840017)

摘要/Abstract

摘要： CRISPR/Cas9基因编辑系统是在古细菌抵御外源核酸入侵的免疫机制基础上人工改造而成的一种新型基因编辑技术。由于其高效率和准确性，CRISPR/Cas9基因编辑技术已经广泛应用于肿瘤治疗的研究中，如靶向敲除致癌基因、修复抑癌基因、打破免疫耐受、构建肿瘤模型等，为肿瘤基因治疗带来革命性的发展。

关键词: 肿瘤, 治疗应用, CRISPR/Cas9基因编辑技术

Abstract: CRISPR/Cas9 gene editing system is a new tool of gene editing technology based on the immune mechanism of archaea against foreign nucleic acid invasion. Due to its high efficiency and accuracy, CRISPR/Cas9 genome editing technology has been widely used in tumor therapeutic research, such as targeted knockout of oncogenes, repair of tumor suppressor genes, breaking immune tolerance, and construction of tumor models, which brings revolutionary development to tumor gene therapy.

Key words: Neoplasms, Therapeutic uses, CRISPR/Cas9 genome editing technique

杨业环，杨成玮，谭小庆，高兴春. CRISPR/Cas9基因编辑技术及其在肿瘤治疗中的应用[J]. 国际肿瘤学杂志, 2018, 45(8): 556-560.

Yang Yehuan, Yang Chengwei, Tan Xiaoqing, Gao Xingchun. CRISPR/Cas9 genome editing system and its application in tumor therapy[J]. Journal of International Oncology, 2018, 45(8): 556-560.

参考文献

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CRISPR/Cas9基因编辑技术及其在肿瘤治疗中的应用

CRISPR/Cas9 genome editing system and its application in tumor therapy

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