国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (5): 281-284.doi: 10.3760/cma.j.issn.1673422X.2018.05.006

• 综述 • 上一篇    下一篇

卷曲螺旋结构域6与肿瘤

孙丹, 辛彦   

  1. 110001 沈阳，中国医科大学附属第一医院肿瘤研究所胃肠肿瘤病理研究室
  • 出版日期:2018-05-08 发布日期:2018-05-23
  • 通讯作者: 辛彦,Email： yxin@cmu.edu.com E-mail: yxin@cmu.edu.com
  • 基金资助:

    国家自然科学基金(81071650)； 辽宁省科技计划(2013225585)

Coiled coil domain containing 6 and tumor

Sun Dan, Xin Yan   

  1. Laboratory of Gastrointestinal Tumor Pathology, Cancer Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Online:2018-05-08 Published:2018-05-23
  • Contact: Xin Yan E-mail: yxin@cmu.edu.com
  • Supported by:

    National Natural Science Foundation of China (81071650); Science and Technology Planning Project of Liaoning Province of China (2013225585)

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摘要： 卷曲螺旋结构域6(CCDC6)最初被发现在甲状腺乳头状癌中参与RET/PTC1融合基因形成。研究表明CCDC6能够在DNA损伤应答修复、细胞周期和凋亡的调控中起重要作用。CCDC6作为抑癌基因，在甲状腺癌、肺癌、结直肠癌、前列腺癌和宫颈癌等多种肿瘤中发挥抑制肿瘤发生、侵袭转移等功能。深入研究CCDC6在肿瘤中的作用及机制，将对肿瘤的诊断、治疗及临床预后评估提供新的思路。

关键词: 肿瘤, 基因融合, 卷曲螺旋结构域6

Abstract: Coiled coil domain containing 6 (CCDC6) is originally found in thyroid papillary carcinoma by participating in RET/PTC1 fusion formation. Studies have shown that CCDC6 plays a vital role in response to DNA damage repair and regulation of cell cycle and apoptosis. As a tumor suppressor, CCDC6 could inhibit tumorgenesis, tumor migration and invasion in thyroid carcinoma, lung cancer, colorectal cancer, prostate cancer and cervical cancer. Intensively study the role and mechanism of CCDC6 in carcinomas will provide a new thought for tumor diagnosis, treatment and clinical prognosis evaluation.  

Key words: Neoplasms, Gene fusion, Coiled coil domain containing 6