中性粒细胞致瘤机制及其与肿瘤转移灶生态龛的相关性

doi:10.3760/cma.j.issn.1673-422X.2017.11.010

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (11): 846-848.doi: 10.3760/cma.j.issn.1673-422X.2017.11.010

中性粒细胞致瘤机制及其与肿瘤转移灶生态龛的相关性

吴玉亮，程忠平

200090 上海，同济大学附属杨浦医院妇产科

收稿日期:2017-07-31 出版日期:2017-11-08 发布日期:2017-11-24
通讯作者: 程忠平 E-mail:mdcheng18@263.net
基金资助:
上海市医学重点专科建设计划（ZA2015A33）

Progress of the tumorigenic mechanism of neutrophil and its relevance to pre-metastatic niche

Wu Yuliang, Cheng Zhongping

Department of Gynaecology and Obstetrics, Affiliated Yangpu Hospital of Tongji University, Shanghai 200090, China

Received:2017-07-31 Online:2017-11-08 Published:2017-11-24
Contact: 程忠平 E-mail:mdcheng18@263.net

摘要/Abstract

摘要： 肿瘤相关中性粒细胞（TAN）在构建、维持和促进肿瘤微环境中扮演重要角色。TAN在不同因素调控下表现出抑制或促进肿瘤的双重作用，既能通过直接杀灭肿瘤细胞、激活免疫应答发挥抑瘤效应，也可通过促进血管生成、介导肿瘤侵袭转移等机制发挥促瘤效应。新近研究发现，TAN还与肿瘤转移灶生态龛（PMN）密切相关，其可通过改变干扰素-γ等细胞因子含量促进PMN的构建和维持。

关键词: 中性白细胞, 肿瘤, 肿瘤转移灶微环境生态龛

Abstract: The tumorassociated neutrophils (TANs) are thought to be important and complicated character in tumor microenvironment. TANs play dual roles of antitumor or tumorpromoting in tumor microenvironment under different factors. TANs can not only play the antitumor effect by killing tumor cells directly and promoting immune response, but also can act as tumor promotors by promoting tumor angiogenesis and mediating tumor invasion and metastasis. Recent researches find that TANs are closely related to premetastatic niche (PMN), which can promote the construction and maintenance of PMN by means of changing the content of cell factors like interferon-γ.

Key words: Neutrophils, Neoplasms, Pre-metastatic niche

吴玉亮，程忠平. 中性粒细胞致瘤机制及其与肿瘤转移灶生态龛的相关性[J]. 国际肿瘤学杂志, 2017, 44(11): 846-848.

吴玉亮，程忠平. Progress of the tumorigenic mechanism of neutrophil and its relevance to pre-metastatic niche[J]. Journal of International Oncology, 2017, 44(11): 846-848.

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中性粒细胞致瘤机制及其与肿瘤转移灶生态龛的相关性

Progress of the tumorigenic mechanism of neutrophil and its relevance to pre-metastatic niche

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