国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 594-596.doi: 10.3760/cma.j.issn.1673-422X.2017.08.009

• 综述 • 上一篇    下一篇

免疫微环境介导的肿瘤耐受机制及其靶向治疗

徐圆圆,张丽,金良昆   

  1. 650000 昆明市第一人民医院肿瘤内科
  • 出版日期:2017-08-08 发布日期:2017-07-21
  • 通讯作者: 金良昆，Email： jinliangkun@126.com E-mail:jinliangkun@126.com
  • 基金资助:

    云南省科技计划（2013FZ220）

Mechanism of tumor tolerance mediated by immune microenvironment and its targeted therapy

Xu Yuanyuan, Zhang Li, Jin Liangkun   

  1. Department of Medical Oncology， First People′s Hospital of Kunming， Kunming 650000, China
  • Online:2017-08-08 Published:2017-07-21
  • Contact: Jin Liangkun, Email： jinliangkun@126.com E-mail:jinliangkun@126.com
  • Supported by:

    Science and Technology Project of  Yunnan Province of  China (2013FZ220)

PDF

1703

摘要： 免疫细胞与其分泌的细胞因子相互作用共同构成免疫微环境，在肿瘤治疗耐受过程中扮演着重要角色。免疫微环境能够通过启动抗凋亡通路、介导免疫耐受、诱导上皮间质转化及形成肿瘤干细胞等途径促进肿瘤产生治疗耐受，降低肿瘤治疗疗效。肿瘤免疫治疗已成为目前肿瘤治疗研究领域的热点。

关键词: 肿瘤, 治疗, 免疫微环境

Abstract: Immune cells interact with their secreted cytokines forming immune microenvironment that plays an important role in the treatment resistance. Immune microenvironment induces tumor tolerance by reducing the antiapoptotic pathway, mediating immune tolerance, inducing epithelial mesenchymal transformation and the formation of tumor stem cells, reducing the curative effect. Tumor immunotherapy has become a hot topic in the field of tumor therapy research.

Key words: Neoplasms, Therapy, Immune microenvironment