胆固醇代谢与恶性肿瘤

doi:10.3760/cma.j.issn.1673-422X.2017.07.011

摘要/Abstract

摘要： 已有研究证实胆固醇代谢在肿瘤发生、发展过程中发挥着重要的作用，同时也在预测恶性肿瘤预后中显示出重要的应用价值。胆固醇可以通过对恶性肿瘤患者进行恰当的风险分层，来提高肿瘤患者远期的生命质量和生存时间。

Abstract: Studies have shown that cholesterol metabolism plays an important role in tumorigenesis and development. At the same time, it is also shown an important application value in predicting the prognosis of malignant tumors. Cholesterol can improve the longterm quality of life and survival of cancer patients by appropriating risk stratification of these malignant tumors.

Key words: Neoplasms, Cholesterol, Cholesterol, HDL, Cholesterol, LDL

师园园，卢宁. 胆固醇代谢与恶性肿瘤[J]. 国际肿瘤学杂志, 2017, 44(7): 522-525.

Shi Yuanyuan, Lu Ning. Cholesterol metabolism and malignant tumors[J]. Journal of International Oncology, 2017, 44(7): 522-525.

参考文献

［1］ Ma LM, Liang ZR, Zhou KR, et al. 27Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells［J］. Biochem Biophys Res Commun, 2016, 480(3): 328-333. DOI: 10.1016/j.bbrc.2016.10.038. ［2］ Alikhani N, Ferguson RD, Novosyadlyy R, et al. Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model［J］. Oncogene, 2013, 32(8): 961-967. DOI: 1038/onc.2012.113. ［3］王瑜敏, 黄海霞, 袁谦. 肺癌患者放疗过程中血脂的动态变化及意义［J］. 江西医学检验, 2015, 23(2): 129-131. ［4］ Chi PD, Liu W, Chen H, et al. Highdensity lipoprotein cholesterol is a favorable prognostic factor and negatively correlated with Creactive protein level in nonsmall cell lung carcinoma［J］. PLoS One, 2014, 9(3): e91080. DOI: 10.1371/journal.pone.0091080. ［5］ Agnoli C, Grioni S, Sieri S, et al. Metabolic syndrome and breast cancer risk: a casecohort study nested in a multicentre italian cohort［J］. PLoS One, 2015, 10(6): e0128891. DOI: 10.1371/journal.pone.0128891. ［6］ Rodrigues Dos Santos C, Fonseca I, Dias S, et al. Plasma level of LDLcholesterol at diagnosis is a predictor factor of breast tumor progression［J］. BMC Cancer, 2014, 14: 132. DOI: 10.1186/1471240714132. ［7］刘业六, 钱海鑫, 秦磊, 等. 血脂相与乳腺癌远处转移的关系［J］. 中华肿瘤杂志, 2012, 34(2): 129131. DOI: 10.3760/cma.j.issn.02533766.2012.02.010. ［8］ Pan B, Ren H, He Y, et al. HDL of patients with type 2 diabetes mellitus elevates the capability of promoting breast cancer metastasis［J］. Clin Cancer Res, 2012, 18(5): 1246-1256. DOI: 10.1158/10780432.CCR110817. ［9］潘巨龙, 严佳斌, 郑玉萍. 乳腺癌骨转移患者血脂和血浆CA153联检对早期诊断的临床价值［J］. 放射免疫学杂志, 2012, 25(4): 463-465. DOI: 10.3969/j.issn.1008-9810.2012.04.055. ［10］ Ghahremanfard F, Mirmohammadkhani M, Shahnazari B, et al. The valuable role of measuring serum lipid profile in cancer progression［J］. Oman Med J, 2015, 30(5): 353-357. DOI: 10.5001/omj.2015.71. ［11］ Wulaningsih W, Garmo H, Holmberg L, et al. Serum lipids and the risk of gastrointestinal malignancies in the Swedish AMORIS study［J］. J Cancer Epidemiol, 2012, 2012: 792034. DOI: 10.1155/2012/792034. ［12］ Tamura T, Inagawa S, Hisakura K, et al. Evaluation of serum highdensity lipoprotein cholesterol levels as a prognostic factor in gastric cancer patient［J］. J Gastroenterol Hepatol, 2012, 27(10): 1635-1640. DOI: 10.1111/j.1440-1746.2012.07189.x. ［13］ Guo E, Chen L, Xie Q, et al. Serum HDLC as a potential biomarker for nodal stages in gastric cancer［J］. Ann Surg Oncol, 2007, 14(9): 2528-2534. DOI: 10.1245/s1043400794010. ［14］ Gorin A, Gabitova L, Astsaturov I. Regulation of cholesterol biosynthesis and cancer signaling［J］. Curt Opin Pharmacol, 2012, 12（6）: 710-716. DOI: 10.1016/j.Coph.2012.06.011. ［15］ Wertheim BC, Smith JW, Fang C, et a1. Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis［J］. Cancer Prey Res (Phila), 2012, 5(2): 197-204. DOI: 10.1158/19406207.CAPR-11-0320. ［16］ Lochhead P, Chan AT. Statins and colorectal cancer［J］. Clin Gastroenterol Hepatol, 2013, 11(2): 109-118. DOI: 10.1016/j.cgh.2012.08.037. ［17］ Liu CS, Hsu HS, Li CI, et al. Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population［J］. BMC Gastroenterol, 2010, 10: 51. DOI: 10.1186/1471-230x-10-51. ［18］ Yang MH, Rampal S, Sung J, et al. The association of serum lipids with colorectal adenomas［J］. Am J Gastroenterol, 2013, 108(5): 833-841. DOI: 10.1038/ajg.2013.64. ［19］ Moon H, Ruelcke JE, Choi E, et al. Dietinduced hypereholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin1［J］. Oncotarget, 2015, 6(10): 7438-7453. DOI: 10.18632/oncotarget.3476. ［20］ Morote J, Celma A, Planas J, et al. Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness［J］. Int J Mol Sci, 2014, 15(8): 13615-13623. DOI: 10.3390/ijms150813615. ［21］ Van Hemelrijck M, Walldius G, Jungner I, et al. Low levels of apolipoproteina AI and HDL are associated with risk of prostate cancer in the Swedish AMORIS study［J］. Cancer Causes Control, 2011, 22(7): 1011-1019. DOI: 10.1007/s10552011-9774-z. ［22］ Seko Y, Akuta N, Suzuki F, et al. Amino acid substitutions in the hepatitis C virus core region and lipid metabolism are associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy［J］. Intervirology, 2013, 56(1): 13-21. DOI: 10.1159/000339993. ［23］ Wolk A, Larsson SC, Johansson JE, et al. Longterm fatty fish consumption and renal cell carcinoma incidence in women［J］. JAMA, 2006, 296(11): 1371-1376. DOI: 10.1001/jama.296.11.1371. ［24］ de Martino M, Leitner CV, Seemann C, et al. Preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma(RCC)［J］. BJU Int, 2015, 115(3): 397-404. DOI: 101111/bju.12767. ［25］徐数娜, 张旭辉, 张日. 急性白血病患者血脂、血糖及蛋白检测的临床意义［J］. 中华临床医师杂志:电子版, 2013, 7(9): 4089-4090. DOI: 10.3877/cma.j.issn.1674-0785.2013.09.127. ［26］ Pereira EB, Gemignani T, Sposito AC, et al. Lowdensity lipoprotein cholesterol and radiotherapyinduced carotid atherosclerosis in subjects with head and neck cancer［J］. Radiat Oncol, 2014, 9: 134. DOI: 10.1186/1748-717X-9-134. ［27］ Borena W, Strohmaier S, Lukanova A, et al. Metabolic risk factors and primary liver cancer in a prospective study of 578, 700 adults［J］. Int J Cancer, 2012, 131(1): 193-200. DOI: 10.1002/ijc. 26338. ［28］杨灿. 血清高密度脂蛋白胆固醇水平用于评价肝脏合成功能的价值［J］. 吉林医学, 2016, 37(7): 1773. DOI: 10.3969/j.issn.10040412.2016.07.137.

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