国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 108-111.doi: 10.3760/cma.j.issn.1673422X.2017.02.007

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长非编码RNA UCA1在肿瘤中的研究进展

严大理, 曹海霞, 冯继锋   

  1. 210009 南京医科大学第四临床医学院；南京医科大学附属肿瘤医院肿瘤内科
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 冯继锋，Email: jifeng_feng@163.com E-mail:jifeng_feng@163.com
  • 基金资助:

     国家自然科学基金（81372396）； 江苏省自然科学基金（BK20141016）

Advances of long non-coding RNA UCA1 in cancers

Yan Dali, Cao Haixia, Feng Jifeng   

  1. Fourth Clinical Medical College of Nanjing Medical University; Department of Medical Oncology, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009,China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Feng Jifeng E-mail:jifeng_feng@163.com
  • Supported by:

    National Natural Science Foundation of China (81372396); Natural Science Foundation of Jiangsu Province of China (BK20141016)

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摘要： 长非编码RNA尿路上皮癌胚抗原1（UCA1）首先于膀胱癌组织中发现并命名，在多种肿瘤组织中如膀胱癌、卵巢癌、肺癌等明显高表达，表现为原癌基因的功能。UCA1可调节肿瘤细胞的增殖、凋亡、转移、侵袭等，在肿瘤的发生、发展中起重要作用，可作为肿瘤诊断、预后及药物敏感性预测的一种新的生物学标志物，并有望成为肿瘤治疗的新靶点。

关键词: 肿瘤, 原癌基因, 尿路上皮癌胚抗原1

Abstract: Long non-coding RNA  urothelial carcinoma associated 1 (UCA1) is initially discovered and named in bladder cancer tissue,  which is highly expressed in multi types of tumor tissues, such as bladder cancer, ovarian cancer, lung cancer, suggesting that UCA1 acts as oncogene. UCA1 is confirmed to regulate tumor cell proliferation, apoptosis, invasion and migration, which plays an important role in the occurrence and development of cancers. UCA1 is expected to become a new biomarker for diagnosis, prognosis and drug susceptibility, which may be a promising therapeutic target of cancer.

Key words: Neoplasms, Protooncogenes, Urothelial carcinoma associated Neoplasms, Proto-oncogenes, Urothelial carcinoma associated 1