关键词: 微RNAs, 肿瘤侵润, 肿瘤转移, 外泌体

Abstract: Tumor microenvironment is the key factor that influences the invasion and metastasis of tumor cells. Exosome is the particle by which cells can make communication in microenvironment. MicroRNA(miRNA) is widely involved in physiological processes, and plays an important role in the stability of tumor environment. MiRNAs in exosome play roles in tumor cell proliferation, extracellular matrix remodeling, and then promote the metastasis, invasion and angiogenesis of tumor. Thus, the expression of oncogenes can be blocked by regulating the exosome production and secretion. It may shed light on the development of a therapeutic strategy for tumor treatment.

Key words: MicroRNAs, Neoplasm invasiveness, Neoplasm metastasis, Exsomes