PI3K信号通路在结直肠癌中的作用

doi:10.3760/cma.j.issn.1673422X.2016.08.018

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 631-633.doi: 10.3760/cma.j.issn.1673422X.2016.08.018

PI3K信号通路在结直肠癌中的作用

王豪,张庆玲

510515 广州，南方医科大学南方医院病理科南方医科大学第一临床医学院（王豪）；南方医科大学南方医院病理科南方医科大学基础医学院病理学系（张庆玲）

出版日期:2016-08-08 发布日期:2016-07-05
通讯作者: 张庆玲，Email: zqllc8@126.com E-mail:zqllc8@126.com
基金资助:
国家自然科学基金（81272760； 81472712）

PI3K signaling pathway in colorectal cancer

Wang Hao, Zhang Qingling

Department of Pathology, Nanfang Hospital, First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China

Online:2016-08-08 Published:2016-07-05
Contact: Zhang Qingling, Email: zqllc8@126.com E-mail:zqllc8@126.com
Supported by:
National Natural Science Foundation of China（81272760； 81472712）

摘要/Abstract

摘要： 结直肠癌(CRC)的早期症状隐匿，多数患者在诊断时已经发生转移。化疗与靶向药物的联合治疗是目前治疗转移性CRC的主要策略，在CRC中高频出现异常激活的磷脂酰肌醇-3-激酶（PI3K）信号通路与CRC的发生发展有着十分密切的关系，对CRC的诊断与治疗具有重要的价值。

关键词: 结直肠肿瘤, 1-磷脂酰肌醇3-激酶, 信号传导, 药物治疗

Abstract: Since the early symptoms are very hidden, most of patients with colorectal cancer (CRC) have occurred metastasis when diagnosed. Recently, chemotherapy combined with targeted therapy is the major therapeutic strategy for metastatic CRC and the high frequency activation of phosphatidylinositol 3-kinase (PI3K) signaling pathway has been validated sharing a close relationship with the development of CRC, contributing important values for the diagnosis and therapy of CRC.

Key words: Colorectal neoplasms, 1-Phosphatidylinositol 3-kinase, Signal transduction, Drug therapy

王豪,张庆玲. PI3K信号通路在结直肠癌中的作用[J]. 国际肿瘤学杂志, 2016, 43(8): 631-633.

Wang Hao, Zhang Qingling. PI3K signaling pathway in colorectal cancer[J]. Journal of International Oncology, 2016, 43(8): 631-633.

参考文献

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PI3K信号通路在结直肠癌中的作用

PI3K signaling pathway in colorectal cancer

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