线粒体DNA突变与胃癌的关系

doi:10.3760/cma.j.issn.1673-422X.2016.08.017

摘要/Abstract

摘要： 线粒体DNA（mtDNA）比核DNA更易受到氧损伤，有较高的突变率。mtDNA改变参与了肿瘤的发生发展, 但这些改变在胃癌进展中的作用仍不清楚。胃癌中位点突变和mtDNA含量变化是两种最常见的导致线粒体功能障碍的mtDNA改变。研究mtDNA这两种改变及与胃癌临床病理学特征之间的关系、探讨mtDNA改变在胃癌中的机制是近年来胃癌研究的新方向。

关键词: DNA, 线粒体, 突变, 胃肿瘤

Abstract: Mitochondrial DNA (mtDNA) is more susceptible to oxidative damage and has a higher mutation rate compared with nuclear DNA due to the absence of protective histone proteins and imperfect repair system. Somatic alterations in mtDNA have been proposed to contribute to initiation and progression of human cancer in previous researches. However, the role of these mtDNA alterations in gastric cancer progression remains unclear. Point mutations and mtDNA content alterations are the two most common mtDNA alterations that result in mitochondrial dysfunction in gastric cancers. Identifing somatic mtDNA alterations in gastric cancers as well as their association with the clinicopathological parameters of gastric cancer, and exploring the causative factors of the somatic mtDNA alterations in cancer progression have been a new direction of gastric cancer research in recent years.

Key words: DNA, mitochondrial, Mutation, Stomach neoplasms

林莉,周福祥. 线粒体DNA突变与胃癌的关系[J]. 国际肿瘤学杂志, 2016, 43(8): 628-630.

Lin Li, Zhou Fuxiang. Relationship between mitochondrial DNA alteration and gastric cancer[J]. Journal of International Oncology, 2016, 43(8): 628-630.

参考文献

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