局部晚期中低位直肠癌新辅助放化疗后病理反应的相关研究进展

doi:10.3760/cma.j.cn371439-20250727-00041

摘要/Abstract

摘要：

局部晚期直肠癌新辅助放化疗后肿瘤降期明显，可提高根治性手术切除率和保肛率，降低局部复发率，从而改善患者预后，但目前缺乏有效的方法来甄别患者对新辅助治疗的反应。研究发现，血液学标志物、肿瘤标志物、核酸标志物等生物学指标以及肿瘤影像学特征与直肠癌新辅助治疗的敏感性相关，可预测术前同步放化疗的敏感性。

关键词: 直肠肿瘤, 肿瘤辅助疗法, 病理完全缓解

Abstract:

Neoadjuvant chemoradiotherapy for locally advanced rectal cancer significantly downstages tumors， which can improve the rate of radical surgical resection and anal sphincter preservation， reduce the local recurrence rate， thereby improving patients' prognosis. However， there is currently a lack of effective methods to identify patients' response to neoadjuvant therapy. Studies have found that biological indicators such as hematological markers， tumor markers， nucleic acid markers， as well as tumor imaging characteristics， are associated with the sensitivity of neoadjuvant therapy for rectal cancer and can predict the sensitivity of preoperative concurrent chemoradiotherapy.

Key words: Rectal neoplasms, Neoadjuvant therapy, Pathological complete response

李志磊, 方金满, 魏丹丹, 孙瑞霞, 张远伟. 局部晚期中低位直肠癌新辅助放化疗后病理反应的相关研究进展[J]. 国际肿瘤学杂志, 2026, 53(4): 248-252.

Li Zhilei, Fang Jinman, Wei Dandan, Sun Ruixia, Zhang Yuanwei. Research progress on pathological response after neoadjuvant chemoradiotherapy in locally advanced middle and low rectal cancer[J]. Journal of International Oncology, 2026, 53(4): 248-252.

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