linc01410在恶性肿瘤发生发展中的作用

doi:10.3760/cma.j.cn371439-20230506-00103

国际肿瘤学杂志 ›› 2023, Vol. 50 ›› Issue (9): 540-543.doi: 10.3760/cma.j.cn371439-20230506-00103

linc01410在恶性肿瘤发生发展中的作用

柳洋¹, 蒋路路², 管凯文¹, 周岳阳¹, 康小红¹()

¹新乡医学院第一附属医院肿瘤科，新乡 453000
²新乡医学院第一附属医院骨科，新乡 453000

收稿日期:2023-05-06 修回日期:2023-05-23 出版日期:2023-09-08 发布日期:2023-10-26
通讯作者: 康小红 E-mail:kxhhgd@163.com
基金资助:
国家自然科学基金(81874392);国家自然科学基金(82074231);河南省科技发展计划(212102310209);河南省医学科技攻关计划(SB201903014);河南省卫生健康科技英才海外研修工程(HWYX2019085)

Role of linc01410 in the occurrence and development of malignant tumors

Liu Yang¹, Jiang Lulu², Guan Kaiwen¹, Zhou Yueyang¹, Kang Xiaohong¹()

¹Department of Oncology， First Affiliated Hospital of Xinxiang Medical University， Xinxiang 453000， China
²Department of Orthopedics， First Affiliated Hospital of Xinxiang Medical University， Xinxiang 453000， China

Received:2023-05-06 Revised:2023-05-23 Online:2023-09-08 Published:2023-10-26
Contact: Kang Xiaohong E-mail:kxhhgd@163.com
Supported by:
National Natural Science Foundation of China(81874392);National Natural Science Foundation of China(82074231);Science and Technology Development Program of Henan Province of China(212102310209);Key Project of Medical Science and Technology of Henan Province of China(SB201903014);Overseas Training Project of Health Science and Technology Talents of Henan Province of China(HWYX2019085)

摘要/Abstract

摘要：

长非编码RNA（lncRNA）是一类长度大于200个核苷酸的高度保守的转录本，对恶性肿瘤的发生、发展和诊疗具有重要的意义。linc01410在恶性肿瘤中异常表达，可通过调控恶性肿瘤细胞的增殖、迁移、上皮间质转化等生物学过程作用于核转录因子-κB、Notch等相关信号通路或通过外泌体途径影响恶性肿瘤的发生发展。

关键词: 肿瘤, RNA，长链非编码

Abstract:

Long non-coding RNA （lncRNA） is a class of highly conserved transcript with a length of more than 200 nucleotides， which is of great significance for the occurrence， development， diagnosis and treatment of malignant tumors. The abnormal expression of linc01410 in malignant tumors can affect the occurrence and development of malignant tumors by regulating the biological processes such as proliferation， migration and epithelial-mesenchymal transformation of malignant tumor cells， acting on related signaling pathways such as nuclear factor-κB and Notch or through exosome pathways.

Key words: Neoplasms, RNA， long noncoding

柳洋, 蒋路路, 管凯文, 周岳阳, 康小红. linc01410在恶性肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2023, 50(9): 540-543.

Liu Yang, Jiang Lulu, Guan Kaiwen, Zhou Yueyang, Kang Xiaohong. Role of linc01410 in the occurrence and development of malignant tumors[J]. Journal of International Oncology, 2023, 50(9): 540-543.

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linc01410在恶性肿瘤发生发展中的作用

Role of linc01410 in the occurrence and development of malignant tumors

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