国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (10): 605-608.doi: 10.3760/cma.j.issn.1673-422X.2019.10.007

• 综述 • 上一篇    下一篇

白血病抑制因子在肿瘤发生发展中的作用

斯赛女1,王华英2,俞万钧2,李纪鹏2   

  1. 1宁波大学医学院临床医学系315100； 2宁波大学医学院附属鄞州医院呼吸与危重症医学科，宁波315100

  • 出版日期:2019-10-08 发布日期:2019-12-20
  • 通讯作者: 俞万钧，Email： nbywj2008@aliyun.com E-mail:nbywj2008@aliyun.com
  • 基金资助:
    浙江省医药卫生科技计划（2017KY615、2018KY749）

Role of leukemia inhibitory factor in tumorigenesis and development

Si Sainyu1, Wang Huaying2, Yu Wanjun2, Li Jipeng2   

  1. 1Department of Clinical Medicine, Medical College, Ningbo University, Ningbo 315100, China; 2Department of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical College of Ningbo University, Ningbo 315100, China

  • Online:2019-10-08 Published:2019-12-20
  • Contact: Yu Wanjun, Email: nbywj2008@aliyun.com E-mail:nbywj2008@aliyun.com
  • Supported by:
    Medical and Health Science and Technology Project  of Zhejiang Province of China (2017KY615, 2018KY749)

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摘要： 白血病抑制因子（LIF）是多功能分泌型细胞因子，可通过JAK激酶/信号转导及转录激活因子3、磷脂酰肌醇3激酶、丝裂原活化蛋白激酶等信号通路在不同肿瘤组织、细胞中发挥作用。LIF在结肠癌、乳腺癌、恶性黑色素瘤、鼻咽癌等多种恶性肿瘤中高表达。高表达的LIF通过促进肿瘤的发生发展增强肿瘤细胞侵袭、迁移能力，降低放化疗敏感性，从而导致患者预后不良。阻断LIF信号通路则可抑制肿瘤进展，LIF有望成为肿瘤治疗的新靶点。

关键词: 肿瘤, 白血病抑制因子, STAT3转录因子

Abstract: Leukemia inhibitory factor (LIF) is a multifunctional secretory cytokine that plays a role in different tumor tissues and cells through janus kinase/signal transducer and activator of transcription 3, phosphatidylinositol 3kinase, mitogen-activated protein kinase signaling pathways. LIF is highly expressed in colorectal cancer, breast cancer, malignant melanoma, nasopharyngeal carcinoma and other malignant tumors. High expression of LIF can promote the development of cancer, increase the ability of tumor invasion and migration, reduce the sensitivity of radiotherapy and chemotherapy, and lead to poor prognosis. Blocking the LIF signaling pathway can inhibit tumor progression, and LIF is expected to become a new target for tumor therapy.

Key words: Neoplasms, Leukemia inhibitory factor, STAT3 transcription factor