国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (5): 366-368.doi: 10.3760/cma.j.issn.1673422X.2017.05.010

• 综述 • 上一篇    下一篇

巡逻单核细胞在肿瘤中的研究进展

方萍,徐可,陈彬,高虹,朱晏伟   

  1. 200062 上海中医药大学附属普陀医院肿瘤科
  • 出版日期:2017-05-08 发布日期:2017-04-19
  • 通讯作者: 朱晏伟，Email: zhuyanwei@csco.org.cn E-mail:zhuyanwei@csco.org.cn
  • 基金资助:

    国家自然科学基金（81503434）

Research progress of the patrolling monocytes in tumor

Fang Ping, Xu Ke, Chen Bin, Gao Hong, Zhu Yanwei   

  1. Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • Online:2017-05-08 Published:2017-04-19
  • Contact: Zhu Yanwei E-mail:zhuyanwei@csco.org.cn
  • Supported by:

    National Natural Science Foundation of China (81503434)

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摘要： 巡逻单核细胞（PMo）是单核细胞的一个亚群，其主要功能是在血管内巡逻，清除微循环中的细胞碎片。研究发现PMo还参与抗肿瘤反应，抑制肿瘤细胞生长，招募自然杀伤细胞（NK）杀伤肿瘤细胞，并防止肿瘤细胞血行转移至肺，起着免疫监视的作用。PMo或许可以成为肿瘤免疫治疗的靶标。

关键词: 肿瘤, 免疫, 单核细胞

Abstract: Patrolling monocyte (PMo) is a subset of monocytes. Its main function is patrolling vascular endothelium and removing cellular debris from the microvasculature. Studies have revealed that PMo can inhibit the growth of tumor cells, recruiting NK cells to kill tumor cells. PMo can prevent tumor cells metastasis to the lung, which plays a role of immunosurveillance. PMo may be a target for cancer immunotherapy.

Key words: Neoplasms, Immune, Monocytes