表观遗传学与鼻咽癌

doi:10.3760/cma.j.issn.1673-422X.2014.05.005

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (5): 335-337.doi: 10.3760/cma.j.issn.1673-422X.2014.05.005

表观遗传学与鼻咽癌

沈建军,张红雁

230000合肥，安徽省立医院肿瘤放射治疗科

收稿日期:2013-12-26 修回日期:2014-01-13 出版日期:2014-05-08 发布日期:2014-04-28
通讯作者: 张红雁 E-mail:takemeparadise@163.com
基金资助:
安徽省自然科学基金（1208085QH169）

Epigenetics and nasopharyngeal carcinoma

Shen Jianjun, Zhang Hongyan

Department of Radiation Oncology, Anhui Provincial Hospital， Hefei 230001, China

Received:2013-12-26 Revised:2014-01-13 Online:2014-05-08 Published:2014-04-28
Contact: Zhang Hongyan E-mail:takemeparadise@163.com

摘要/Abstract

摘要： 鼻咽癌的发病原因至今尚不十分清楚，最新的证据表明表观遗传学参与了鼻咽癌的发生发展。表观遗传学改变可以作为鼻咽癌的分子指标，有利于判断预后。针对表观遗传学改变采取干预措施未来可作为新的鼻咽癌治疗手段，并且可以开发新的鼻咽癌放疗增敏剂和新的治疗药物。研究表观遗传学在鼻咽癌中的改变，为鼻咽癌的诊断、治疗等提供了新的思路。

关键词: 鼻咽肿瘤, 遗传, 甲基化

Abstract: The etiology of nasopharyngeal carcinoma is still not very clear. Epigenetics is proved to play an important role in the occurrence and development of nasopharyngeal carcinoma (NPC). Detection of epigenetics can serve as molecular index of NPC, and it is advantageous to the prognosis and disease of NPC. Different intervention measures in the epigenetics can be used as a new treatment of NPC, as well as the development of new NPC radiotherapy sensitization agent and new drugs. Study of epigenetics changes in nasopharyngeal carcinoma provides a new idea for the diagnosis and treatment in NPC and so on.

Key words: Nasopharyngeal neoplasms, Heredity, Methylation

沈建军,张红雁. 表观遗传学与鼻咽癌[J]. 国际肿瘤学杂志, 2014, 41(5): 335-337.

Shen Jianjun, Zhang Hongyan. Epigenetics and nasopharyngeal carcinoma[J]. Journal of International Oncology, 2014, 41(5): 335-337.

参考文献

［1］ Welberg L. Epigenetics: keeping it in the family［J］. Nat Rev Neurosci, 2013, 14(7):458-459. ［2］ Szulwach KE, Jin P. Integrating DNA methylation dynamics into a framework for understanding epigenetic codes［J］. Bioessays, 2014, 36(1):107-117. ［3］ Panayiotidis MI. Cancer epigenetics as biomarkers of clinical significance［J］. Cancer Lett, 2014, 342(2):168-169. ［4］ Wright R, Saul RA. Epigenetics and primary care［J］. Pediatrics, 2013, 132 Suppl 3:S216-223. ［5］ Johnson C, Warmoes MO, Shen X, et al. Epigenetics and cancer metabolism［J］. Cancer Lett, 2013, In press. ［6］ Ponomarev I. Epigenetic control of gene expression in the alcoholic brain［J］. Alcohol Res, 2013, 35(1):69-76. ［7］ Lawrence J. Interview: from down′s syndrome to basic epigenetics and back again ［J］. Epigenomics, 2013, 5(6):611-614. ［8］ Zhong X, Zhu Y, Mao J, et al. Frequent epigenetic silencing of PCDH10 by methylation in human colorectal cancer［J］. J Cancer Res Clin Oncol, 2013, 139(3):485-490. ［9］ Zhao Y, Zhou H, Ma K, et al. Abnormal methylation of seven genes and their associations with clinical characteristics in early stage nonsmall cell lung cancer［J］. Oncol Lett, 2013, 5(4):1211-1218. ［10］ Yu YP, Ding Y, Chen R, et al. Wholegenome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer［J］. Am J Pathol, 2013, 183(6):1960-1970. ［11］谭双香, 易红, 汤参娥, 等. 鼻咽癌细胞株1433σ启动子去甲基化与基因表达研究［J］. 国际肿瘤学杂志, 2008, 35(4):312-315. ［12］ Lan J, Tai HC, Lee SW, et al. Deficiency in expression and epigenetic DNA methylation of ASS1 gene in nasopharyngeal carcinoma: negative prognostic impact and therapeutic relevance［J］. Tumour Biol, 2014, 35(1):161-169. ［13］ Yan C, Liu C, Jin Q, et al. The promoter methylation of the Syk gene in nasopharyngeal carcinoma cell lines ［J］. Oncol Lett, 2012, 4(3):505-508. ［14］ Kim JG, Park MT, Heo K, et al. Epigenetics meets radiation biology as a new approach in cancer treatment［J］. Int J Mol Sci, 2013, 14(7):15059-15073. ［15］ Hofsteeeer B, Niemiertko A, Forrer C, et al. Impact of genomic methylation on radiation sensitivity of colorectal carcinoma［J］. Int J Radiat Oncol Biol Phys, 2010, 76(5):1512-1519. ［16］ Karapetyan AR, Buiting C, Kuiper RA, et al. Regulatory roles for long ncRNA and mRNA［J］. Cancers (Basel), 2013, 5(2):462-490. ［17］ Liu N, Chen NY, Cui RX, et al. Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis［J］. Lancet Oncol, 2012, 13(6):633-641. ［18］ Zhang LY, HoFun Lee V, Wong AM, et al. MicroRNA144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN［J］. Carcinogenesis, 2013, 34(2):454-463. ［19］ Zhang Y, Chen X, Ren P, et al. Synergistic effect of combination topotecan and chronomodulated radiation therapy on xenografted human nasopharyngeal carcinoma ［J］. Int J Radiat Oncol Biol Phys, 2013, 87(2):356-362. ［20］ Li B, Huang G, Zhang X, et al. Increased phosphorylation of histone H3 at serine 10 is involved in EpsteinBarr virus latent membrane protein1induced carcinogenesis of nasopharyngeal carcinoma［J］. BMC Cancer, 2013, 13:124. ［21］陈济, 刘定义. 表观遗传调控与胃癌［J］. 国际肿瘤学杂志, 2012, 39(4): 292-295. ［22］ Ritchie EK, Feldman EJ, Christos PJ, et al. Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia［J］. Leuk Lymphoma, 2013, 54(9):2003-2007.

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表观遗传学与鼻咽癌

Epigenetics and nasopharyngeal carcinoma

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