肿瘤乏氧分子靶向治疗

doi:10.3760/cma.j.issn.1673-422X.2014.05.003

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (5): 327-331.doi: 10.3760/cma.j.issn.1673-422X.2014.05.003

肿瘤乏氧分子靶向治疗

李姗姗,邢力刚,孙晓蓉

250117 济南大学山东省医学科学院医学与生命科学学院;山东省肿瘤医院放疗科（李姗姗、邢力刚），PET-CT中心（孙晓蓉）

收稿日期:2013-11-18 修回日期:2014-01-15 出版日期:2014-05-08 发布日期:2014-04-28
通讯作者: 邢力刚 E-mail:xinglg@medmail.com.cn
基金资助:
国家自然科学基金（81001004）；山东省自然科学基金（ZR2010HL027）

Molecular targeted therapy of tumor hypoxia

Li Shanshan, Xing Ligang, Sun Xiaorong

School of Medical and Life Sciences， University of Ji′nan-Shandong Academy of Medical Sciences； Department of Radiation Oncology, Shandong Cancer Hospital, Ji′nan 250117, China

Received:2013-11-18 Revised:2014-01-15 Online:2014-05-08 Published:2014-04-28
Contact: Xing Ligang E-mail:xinglg@medmail.com.cn

摘要/Abstract

摘要： 乏氧是多数实体瘤的固有特征之一，可增加肿瘤细胞对放化疗的耐受性、促使肿瘤血管生成，是重要的不良预后因素。靶向杀伤肿瘤内的乏氧细胞成为肿瘤治疗的热点。生物还原性药物可通过特定的还原反应激活为细胞毒性代谢产物进而杀伤乏氧肿瘤细胞，而小分子靶点抑制剂则选择性地作用于乏氧途径中的关键环节，二者为肿瘤的乏氧靶向治疗开辟了新的途径。

关键词: 肿瘤, 缺氧, 分子靶向治疗

Abstract: Hypoxia is an inherent feature of the majority of solid tumors, which can increase the resistance of tumor cells to radiotherapy and chemotherapy, promote tumor angiogenesis and lead to poor prognosis. Therefore, targeting the hypoxic tumor cells has become a spot in cancer therapy. Bioreduction drugs can be activated by a specific reduction to become cytotoxic metabolites, thus killing hypoxic tumor cells, while small molecular targeting inhibitors can selectively act on the key point of hypoxia pathway. They have paved a new way for hypoxia targeted therapy.

Key words: Neoplasms, Anoxia, Molecular targeted therapy

李姗姗,邢力刚,孙晓蓉. 肿瘤乏氧分子靶向治疗[J]. 国际肿瘤学杂志, 2014, 41(5): 327-331.

Li Shanshan, Xing Ligang, Sun Xiaorong. Molecular targeted therapy of tumor hypoxia[J]. Journal of International Oncology, 2014, 41(5): 327-331.

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肿瘤乏氧分子靶向治疗

Molecular targeted therapy of tumor hypoxia

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